| Project/Area Number |
21790728
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Ehime University |
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Principal Investigator |
OGIMOTO Akiyoshi Ehime University, 医学部附属病院, 講師 (00403832)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 臨床心血管病態学 / 肥大型心筋症 / 遺伝子多型 / 予後 / Hypertrophic cardiomyopathy / Polymorphism / gene / Cardiovascular events / B-type natriuretic peptide |
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| Research Abstract |
The aim of this study was to investigate the pharmacogenetic interactions and the association between modifier gene polymorphisms and cardiovascular events in patients with hypertrophic cardiomyopathy (HCM). Obstructive HCM patients with the angiotensin-converting enzyme (ACE) D allele had a high left ventricular pressure gradient. Cibenzoline was more effective in obstructive HCM patients with the ACE D allele. In addition, a common genetic variant (rs632793) in the NPPB gene was found to be associated with circulating BNP concentrations and cardiovascular events in patients with HCM.
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