Novel pharmacotherapy for ischemic heart disease with cardioprotective activity of endogenous acetylcholine.
| Project/Area Number |
21790729
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
ARIKAWA Mikihiko Kochi University, 教育研究部医療学系, 助教 (20432817)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 生体機能利用 / 心機能保護 / コリンエステラーゼ阻害剤 / アセチルコリン |
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| Research Abstract |
In the present study, we investigated the acute effect of donepezil, an acetylcholinesterase inhibitor, on cardiac dysfunction and remodeling during an acute phase of myocardial infarction (MI) in mice. As results, donepezil inhibited matrix metalloproteinase-9 (MMP-9)-related acute inflammatory tissue injury in the infarcted myocardium, thereby reduced the risk of left ventricular free wall rupture during the acute phase of MI.
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Report
(3 results)
Research Products
(18 results)
