Development of a Novel Minimally Invasive Therapy Based on Pulse-infusion DDS Catheter for Coronary Arterial Diseases

• Project/Area Number: 21790732
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyushu University
• Principal Investigator: NAKANO Kaku Kyushu University, 大学院・医学研究院, 学術研究員 (30420607)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 分子血管病態学 / プラーク破綻 / マクロファージ / ナノ粒子 / ナノテクノロジー / DDS / 低侵襲医療 / 生理活性ペプチド

Research Abstract

We developed bio-absorbable nanoparticles which has efficacy drug delivery system. Furthermore, fluorescent marker incorporated nanoparticles were administrated into balloon injured rabbit and porcine coronary arteries using an infusion catheter system. Nanoparticles were observed and retentive until up to 28 days. Drug incorporated nanoparticles significantly attenuated neointimal formation as compared with vehicle control group.

Research Products

• [Journal Article] Nanoparticle-Mediated Delivery of Pitavastatin Into Lungs Ameliorates the Development and Induces Regression of Monocrotaline-Induced Pulmonary Artery Hypertension. (2011)
  • Author(s): Chen L, et al.
  • Journal Title: Hypertension. Volume: 57(2) Pages: 343-350
  • Peer Reviewed
• [Journal Article] Nanoparticle-Mediated Endothelial Cell-Selective Delivery of Pitavastatin Induces Functional Collateral Arteries(Therapeutic Arteriogenesis)in a Rabbit Model of Chronic Hindlimb Ischemia. (2010)
  • Author(s): Oda S, Nagahama R, Nakano K, Matoba T, Kubo M, Sunagawa K, Tominaga R, Egashira K
  • Journal Title: J Vasc Surg. 52(2) Pages: 412-420
• [Journal Article] Nanoparticle-Mediated Delivery of Pitavastatin Into Lungs Ameliorates the Development and Induces Regression of Monocrotaline-Induced Pulmonary Artery Hypertension. (2010)
  • Author(s): Chen L, Nakano K, Kimura S, Matoba T, Iwata E, Miyagawa M, Tsujimoto H, Nagaoka K, Kishimoto J, Sunagawa K, Egashira K
  • Journal Title: Hypertension. 57(2) Pages: 343-350
• [Journal Article] Nanoparticle-Mediated Endothelial Cell-Selective Delivery of Pitavastatin Induces Functional Collateral Arteries (Therapeutic Arteriogenesis) in a Rabbit Model of Chronic Hindlimb Ischemia. (2010)
  • Author(s): Oda S, et al.
  • Journal Title: J Vasc Surg. Volume: 52(2) Pages: 412-420
  • Peer Reviewed
• [Journal Article] 総説 ナノテクノロジーの循環器疾患への応用 (2010)
  • Author(s): 中野覚、江頭健輔
  • Journal Title: 呼吸と循環 Volume: 58(5) Pages: 495-501
• [Journal Article] Nanoparticle-Mediated Delivery of Nuclear FactorκB Decoy Into Lungs Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension. (2009)
  • Author(s): Kimura S, Egashira K, Chen L, Nakano K, Iwata E, Miyagawa M, Tsujimoto H, Hara K, Morishita R, Sueishi K, Tominaga R, Sunagawa K
  • Journal Title: Hypertension. 53(5) Pages: 877-883
• [Journal Article] Formulation of nanoparticle-eluting stents by a cationic electrodeposit coating technology: Efficient and safe nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries. (2009)
  • Author(s): Nakano K, Egashira K, Masuda S, Funakoshi K, Zhao G, Kimura S, Matoba T, Sueishi K, Endo Y, Kawashima Y, Hara K, Tsujimoto H, Tominaga R, Sunagawa K
  • Journal Title: J Am Coll Cardiol : Cardovasular Intervention. 2(4) Pages: 277-283
  • NAID: 130006292652
• [Journal Article] Therapeutic Neovascularization by Nanotechnology-Mediated Cell-Selective Delivery of Pitavastatin into the Vascular Endothelium. (2009)
  • Author(s): Kubo M, Egashira K, Inoue T, Koga J, Oda S, Chen L, Nakano K, Matoba T, Kawashima Y, Hara K, Tsujimoto H, Sueishi K, Tominaga R, Sunagawa K
  • Journal Title: Atheroscler Thromb Vasc Biol. 29 Pages: 796-801
• [Journal Article] 総説ナノテクノロジーの循環器疾患への応用. (2009)
  • Author(s): 中野覚、江頭健輔
  • Journal Title: 医学書院 呼吸と循環 58(5) Pages: 495-501
• [Journal Article] Local Delivery of Imatinib Mesylate (STI571) Incorporated Nanoparticle Ex Vivo Suppresses Vein Graft Neointima Formation. (2009)
  • Author(s): Kimura S, et al.
  • Journal Title: Circulation. 118
  • Peer Reviewed
• [Journal Article] Nanoparticle-Mediated Delivery of Nuclear Factor κ_B Decoy Into Lungs Ameliorates Monocrotaline-Induced Pulmonary Arterial. (2009)
  • Author(s): Kimura S, et al.
  • Journal Title: Hypertension. 53(5) Pages: 877-883
  • Peer Reviewed
• [Journal Article] Formulation of nanoparticle-eluting stents by a cationic electrodeposit coating technology : Efficient and safe nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries. (2009)
  • Author(s): Nakano K, et al.
  • Journal Title: JACC : Cardiovascular Intervention 2(4) Pages: 277-283
  • NAID: 130006292652
  • Peer Reviewed
• [Journal Article] Therapeutic neovascularization by nanotechnology-mediated cell-selective delivery of pitavastatin into the vascular endothelium. (2009)
  • Author(s): Kubo M, et al.
  • Journal Title: Arterioscler Thromb Vasc Biol. 29(6) Pages: 796-801
  • Peer Reviewed
• [Presentation] Pitavastatin-incorporated Nanoparticle-eluting Stents Attenuate in-stent Stenosis without Delayed Endothelial Healing Effects of Sirolimus-eluting Stent Sites in a Porcine Coronary Artery Model (2010)
  • Author(s): Ling Chen, Kaku Nakano, Tetsuya Matoba, Kenji Sunagawa, Kensuke Egashira
  • Organizer: 第19回International Conference of the Cardiovascular System Dynamics Society
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-26
• [Presentation] Pitavastatin-incorporated Nanoparticle-eluting Stents Attenuate in-stent Stenosis without Delayed Endothelial Healing Effects of Sirolimus-eluting Stent Sites in a Porcine Coronary Artery Model (2010)
  • Author(s): 中野覚, 他
  • Organizer: 19th International Conference of the Cardiovascular System Dynamics Society
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-26
• [Presentation] Pitavastatin incorporated nanoparticle-eluting stents attenuate in-stent stenosis without anti-healing effects induced by sirolimus-eluting stents(Cypher)in porcine coronary artery model (2010)
  • Author(s): Kaku Nakano, Tetsuya Matoba, Kenji Sunagawa, Kensuke Egashira
  • Organizer: 第74回日本循環器学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-07
• [Presentation] スタチン封入ナノ粒子溶出ステントは血管修復を促進しステント内狭窄を抑制する-シロリムス溶出ステントとの比較試験‐ (2009)
  • Author(s): 中野覚、月江教昭、江頭健輔
  • Organizer: 第17回日本血管生物医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-08
• [Presentation] スタチン封入ナノ粒子溶出ステントは血管修復を促進しステント内狭窄を抑制する-シロリムス溶出ステントとの比較試験- (2009)
  • Author(s): 中野覚, 他
  • Organizer: 第17回日本血管生物医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-08
• [Presentation] ナノテクノロジーを基盤としたナノDDSステントの開発とブタ冠動脈モデルにおけるピタバスタチンナノDDSステントの有効性と安全性 (2009)
  • Author(s): 中野覚, 他
  • Organizer: 第17回日本血管生物医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-08
• [Presentation] Pitavastatin Incorporated Nanoparticle-Eluting Stent Attenuates In-Stent Stenosis, and Prevents Adverse Effects of Silorimus-Eluting Cypher Stent in Porcine Coronary Artery Model (2009)
  • Author(s): Kaku Nakano, Kensuke Egashira
  • Organizer: 第41回日本動脈硬化学会
  • Place of Presentation: 山口
  • Year and Date: 2009-07-17
• [Presentation] Pitavastatin has most Potent Pro-healing Effects on Endothelial Cells and Inhibitory Effects on Proliferation of Vascular Smooth Muscle Cells -A Potential Treatment Strategy for Drug-Eluting Stents (2009)
  • Author(s): Kaku Nakano, Kensuke Egashira
  • Organizer: 第41回日本動脈硬化学会
  • Place of Presentation: 山口
  • Year and Date: 2009-07-17
• [Presentation] Formulation of nanoparticle-eluting stents by a cationic electrodeposit coating technology: Efficient and safe nano-drug delivery via bioabsorbable polymeric nanoparticle-eluting stents in porcine coronary arteries (2009)
  • Author(s): Nakano K, Egashira K, Masuda S, Funakoshi K, Zhao G, Kimura S, Matoba T, Sueishi K, Endo Y, Kawashima Y, Hara K, Tsujimoto H, Tominaga R, Sunagawa K
  • Organizer: 第41回日本動脈硬化学会
  • Place of Presentation: 山口
  • Year and Date: 2009-07-17
• [Presentation] Formulation of Nanoparticle-Eluting Stent by a Cationic Electrodeposition Coating Technology : Efficient Nano-Drug Delivery via Bioabsorbable Polymeric Nanoparticle-Eluting Stents in Porcine Coronary Arteries. (2009)
  • Author(s): Nakano K, et al.
  • Organizer: 第41回日本動脈硬化学会
  • Place of Presentation: 下関
  • Year and Date: 2009-07-17
• [Presentation] Pitavastatin incorporated nanoparticle-eluting stents attenuate in-stent stenosis without anti-healing effects induced by sirolimus-eluting stents (Cypher) in porcine coronary artery model. (2009)
  • Author(s): Nakano K, et al.
  • Organizer: 第74回日本循環器学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-07
• [Book] 血管医学(薬剤溶出ステントと遅発性血管症-DESの陰から光を探る- ナノDDSステントの創製と臨床応用)10(2) (2009)
  • Author(s): 中野覚、江頭健輔
  • Publisher: メディカルレビュー社
• [Book] 次世代型冠動脈ステント開発の現状と展望 30(6) (2009)
  • Author(s): 中野覚、江頭健輔
  • Total Pages: 3
  • Publisher: Medical ViewPoint株式会社医事出版社
• [Book] Medical View Point (2009)
  • Author(s): 中野覚, 他
  • Total Pages: 3
  • Publisher: 株式会社医事出版社
• [Remarks] ホームページ等
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/1_sentaniryo/staff/index2.html
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/cardiol/