| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Activated (M1) macrophage plays a primary role in atherosclerotic plaque destabilization and rupture. The author hypothesized that regulating macrophage M1/M2 polarity toward anti-inflammatory M2 enable to prevent atherosclerotic plaque destabilization and rupture. In ApoE-KO mice, nanoparticle-mediated monocyte-selective treatment with PPAR-gamma agonist inhibited macrophage M1 shift, and reduced incidence of plaque rupture in the brachiocephalic arteries. These results proved the concept of a new therapy for preventing plaque rupture, by regulating macrophage polarity.
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