| Project/Area Number |
21790735
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
KITAMOTO Shiro Kyushu University, 大学院・医学研究院, 客員助教 (00380436)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 動脈硬化 / キチナーゼ / マクロファージ / 炎症 / コレステロール代謝 |
|---|
| Research Abstract |
Experiments overexpressing or inhibiting chitinase in cultured macrophages revealed that chitinase increased CD36, ABCA1, and ABCG1 expression via PPARγ and LXRα pathway, promoted cholesterol uptake and Apo-AI dependent cholesterol efflux, and decreased inflammatory cytokines MCP-1 and TNFα expression by suppressing AP-1 transcriptional activity. Administration of chitinase inhibitor increased atherosclerotic lesion in ApoE knockout mice. These data suggest that chitinase has anti-atherosclerotic effects.
|
