| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Chronic heart failure(CHF) is a prevalent syndrome with poor prognosis, especially the major cause of death and re-hospitalization in the elderly, and secondary prevention is important. Identification of factors that contribute to increased mortality might lead to the development of a new strategy to improve survival of CHF. It has been reported that about 50% of CHF patients have sleep apnea syndrome(SAS), which consists of obstructive sleep apnea(OSA) and Cheyne-Stokes respiration(CSR). Adaptive servo ventilation(ASV) is a ventilator support system specifically designed to normalize ventilation in patients with CSR and OSA. ASV can regulate the airway ventilation volume according to the demand based on the variable tidal volume throughout the period of CSR. It has been reported that ASV can improve not only SAS but also cardiac function. We demonstrate that short and long term effects of ASV on heart failure with CSR. Adaptive servo ventilation might be a promising useful tool for chronic heart failure as an important non-pharmacotherapy.
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