| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
ABCA1 expression is regulated negatively by a transcriptional factor AP2 and its protein level is modulated by calpain-mediated proteolytic degradation. In this research project, I demonstrated that regulation of the ABCA1 gene by AP2 is mediated by its phosphorylation by PKD, which is similar to negative regulation of the adiponectin gene. I also showed that calmodulin binds ABCA1 and suppress its calpain-mediated degradation. A calmodulin inhibitor W7 enhanced calmodulin binding to ABCA1 to increase HDL biogenesis.
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