The role of IQGAP1 in heart failure prevention
Project/Area Number |
21790743
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
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Research Institution | Kitasato University |
Principal Investigator |
TOJO Minako (TOJO YAMAOKA Minako) 北里大学, 医療衛生学部, 准教授 (80327345)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 心不全 / 臓器保護 / 血管新生 / 予防医学 / 虚血再灌流 |
Research Abstract |
We investigated the role of IQ motif-containing GTPase-activating protein 1(IQGAP1), a scaffold protein for growth factor signaling and production of reactive oxygen species, on cardiac remodeling in response to ischemic heart damage using heart derived culture cells. IQGAP1 may be an important modulator for heart failure prevention, especially in extra matrix cell growth of the heart.
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Report
(4 results)
Research Products
(94 results)
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[Journal Article] Usefulness of pet ownership as a modulator of cardiac autonomic imbalance in patients with diabetes mellitus, hypertension and/or hyperlipidemia2012
Author(s)
Aiba N, Hotta K, Yokoyama M, Wang G, Tabata M, Kamiya K, Shimizu R, Kamekawa D, Hoshi K, Yamaoka-Tojo M, Masuda T
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Journal Title
Am J Cardiol.2012 Jan 23
Volume: (Epub ahead of print)(In press)
Issue: 8
Pages: 1164-1170
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of ezetimibe add-on therapy for high-risk patients with dyslipidemia.2009
Author(s)
Yamaoka-Tojo M, Tojo T, Kosugi R, Hatakeyama Y, Yoshida Y, Machida Y, Aoyama N, Masuda T, Izumi T. Yamaoka Tojo M, Tojo T, Masuda T, Izumi T.
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Journal Title
Lipids in Health and Disease. 8:41
Pages: 1-8
Related Report
Peer Reviewed
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[Presentation] Soluble Fms-Like Tyrosine Kinase 1 is a novel predictor of cardiovascular disease progression in patients with coronary artery disease (11051/2023)2011
Author(s)
Kameda R, Yamaoka-Tojo M, Tojo T, Wakaume K, Nemoto S, Kitasato L, Yoshida Y, Shimohama T, Machida Y, Izumi T
Organizer
米国心臓病学会(AHA2011)
Place of Presentation
Orland, FL, USA
Year and Date
2011-11-15
Related Report
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[Presentation] Association between Pentraxin 3 and renal function in patients at high risk of cardiovascular disease2011
Author(s)
Kameda R, Yamaoka-Tojo M, Tojo T, Wakaume K, Nemoto S, Kitasato L, Yoshida Y, Hatakeyama Y, Machida Y, Izumi T.
Organizer
The 15th Annual Scientific Meeting of Japanese Heart Failure Society
Place of Presentation
Kagoshima, Japan
Year and Date
2011-10-13
Related Report
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[Presentation] Functional arterial stiffness predicts a thickening of carotid intima-media one year later in patients with lifestyle-related disease2011
Author(s)
Ogura NM, Kamekawa D, Kamiya K, Matsunaga A, Kimura M, Shimizu R, Ogura T, Noda C, Yamaoka-Tojo M, Masuda T.
Organizer
ESC 2011
Place of Presentation
Paris, France
Year and Date
2011-08-30
Related Report
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[Presentation] Functional arterial stiffness predicts a thickening of carotid intima-media one year later in patients with lifestyle-related disease2011
Author(s)
Ogura NM, Kamekawa D, Kamiya K, Matsunaga A, Kimura M, Shimizu R, Ogura T, Noda C, Yamaoka-Tojo M, Masuda T
Organizer
欧州心臓病学会(ESC2011)
Place of Presentation
Paris, France
Year and Date
2011-08-30
Related Report
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[Presentation] Increased physical activity decreases circulating pentraxin 3 levels in patients at high risk of cardiovascular disease2011
Author(s)
Wakaume K, Yamaoka-Tojo M, Nemoto S, Kameda R, Aiba N, Tojo T, Yoshida Y, Machida Y, Masuda T, Izumi T.
Organizer
ESC 2011
Place of Presentation
Paris, France
Year and Date
2011-08-29
Related Report
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[Presentation] The plasma levels of B-type natriuretic peptide is a useful predictor of cardiac events for out-clinic patients with asymptomatic heart failure who are in stable condition2011
Author(s)
Yamaoka-Tojo M, Kitasato L, Nemoto S, Wakaume K, Kameda R, Yoshida Y, Machida Y, Tojo T, Kasuda T, Izumi T.
Organizer
ESC 2011
Place of Presentation
Paris, France
Year and Date
2011-08-29
Related Report
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[Presentation] Increased physical activity decreases circulating pentraxin 3 levels in patients at high risk of cardiovascular disease2011
Author(s)
Wakaume K, Yamaoka-Tojo M, Nemoto S, Kameda R, Aiba N, Tojo T, Yoshida Y, Machida Y, Masuda T, Izumi T
Organizer
欧州心臓病学会(ESC2011)
Place of Presentation
Paris, France
Year and Date
2011-08-29
Related Report
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[Presentation] The plasma levels of B-type natriuretic peptide is a useful predictor of cardiac events for out-clinic patients with asympt omatic heart failure who are in stable condition2011
Author(s)
Yamaoka-Tojo M, Kitasato L, Nemoto S, Wakaume K, Kameda R, Yoshida Y, Machida Y, Tojo T, Kasuda T, Izumi T
Organizer
欧州心臓病学会(ESC2011)
Place of Presentation
Paris, France
Year and Date
2011-08-29
Related Report
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[Presentation] The change of circulating interleukin-18 is associated with the change of arteriosclerosis, a 5-year observational study from Kitasato Registry of Cardiovascular Disease Prevention2011
Author(s)
Kameda R, Yamaoka-Tojo M, Wakaume K, Tojo T, Aiba N, Yoshida Y, Machida Y, Matsimaga A, Masuda T, Izumi T
Organizer
第75回日本循環器学会総会・学術集会
Place of Presentation
パシフィコ横浜(横浜)(e-poster)
Year and Date
2011-08-04
Related Report
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[Presentation] Regular physical activity prevents atherosclerosis in high-risk patients with cardiovascular disease2011
Author(s)
Nemoto S, Yamaoka-Tojo M, Wakaume K, Yamamoto S, Kimura M, Ogura M, Aiba N, Kameda R, Machida Y, Yoshida Y, Matsunaga A, Masuda T, Izumi T.
Organizer
American College of Sports Medicine
Place of Presentation
Denver, CO, USA
Year and Date
2011-05-31
Related Report
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[Presentation] Regular physical activity prevents atherosclerosis in high-risk patients with cardiovascular disease2011
Author(s)
Nemoto S, Yamaoka-Tojo M, Wakaume K, Yamamoto S, Kimura M, Ogura M, Aiba N, Kameda R, Machida Y, Yoshida Y, Matsunaga A, Masuda T, Izumi T
Organizer
米国スポーツ医学会(American College of Sports Medicine ; ACSM)
Place of Presentation
Denver, CO, USA
Year and Date
2011-05-31
Related Report
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[Presentation] The change of circulating interleukin-18 is associated with the change of arteriosclerosis, a 5-year observational study from Kitasato Registry of Cardiovascular Disease Prevention2011
Author(s)
Kameda R, Yamaoka-Tojo M, Wakaume K, Tojo T, Aiba N, Yoshida Y, Machida Y, Matsunaga A, Masuda T, Izumi T.
Organizer
The 75th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Yokohama
Related Report
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[Presentation] Lifestyle modification-improving systemic athero-protective factor, circulating pentraxin 3, in high-risk patients with metabolic syndrome2010
Author(s)
Yamaoka-Tojo M, Tojo T, Wakaume K, Kameda R, Takahira N, Aoyama N, Matsunaga A, Masuda T, Izumi T.
Organizer
AHA2010
Place of Presentation
Chicago, IL, USA
Year and Date
2010-11-15
Related Report
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[Presentation] Decreased strength of quadriceps increases the risk of mortality in patients with chronic heart failure2010
Author(s)
Kamiya K, Masuda T, Matsunaga A, Miida K, Ogura MN, Kimura M, Noda C, Yamaoka-Tojo M, Inomata T, Izumi T.
Organizer
AHA2010
Place of Presentation
Chicago, IL, USA
Year and Date
2010-11-15
Related Report
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[Presentation] Decreased strength of quadriceps increases the risk of mortality in patients with chronic heart failure.2010
Author(s)
Kamiya K, Masuda T, Matsunaga A, Miida K, Ogura MN, Kimura M, Noda C, Yamaoka-Tojo M., et al.
Organizer
米国心臓病協会学術集会(AHA 2010)
Place of Presentation
Chicago, IL, USA
Year and Date
2010-11-15
Related Report
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[Presentation] 糖尿病を合併した高血圧患者の糖・脂質代謝及び腎機能に対するL型およびN型のカルシウムチャネルブロッカーの効果-L型カルシウムチャネルブロッカーとの比較.2009
Author(s)
増田卓, 小倉彩, 山本壱弥, 鈴木秀俊, 清水良祐, 亀川大輔, 饗庭尚子, 田畑稔, 小松麻美, 横山美佐子, 野田千春, 東條美奈子, 和泉徹.
Organizer
第32回日本高血圧症学会
Place of Presentation
滋賀
Year and Date
2009-10-02
Related Report
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