Analysis for mechanism of ventricular and atrial cardiomyocyte differentiation in pluripotent stem cells
Project/Area Number |
21790746
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Keio University |
Principal Investigator |
TANAKA Tomofumi Keio University, 医学部, 研究員 (20468482)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 多能性幹細胞 / ES細胞 / iPS細胞 / 分化誘導 / 心筋細胞 / 再生医学 / ips細胞 / 心室筋 / 心房筋 |
Research Abstract |
It has been appreciated that ES/iPS cells can differentiate into heterogeneous populations of atrial, ventricular, and specialized conduction cardiomyocytes in culture. We found that transient inhibition of BMP signaling by Noggin and ascorbic acid treatment induced atrial cardiomyocyte differentiation of mouse ES and human iPS cells. Furthermore, we found that G-CSF treatment enhanced proliferations of human iPS cell-derived cardiomyocytes.
|
Report
(3 results)
Research Products
(1 results)