Physiological and pathophysiological effects of aldosterone on cardiomyocytes through a dynamic regulation of insulin signaling.

• Project/Area Number: 21790753
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Jikei University School of Medicine
• Principal Investigator: NAGOSHI Tomohisa Jikei University School of Medicine, 医学部, 助教 (60408432)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: アルドステロン / インスリンシグナル / 心筋細胞 / 糖代謝

Research Abstract

Aldosterone and insulin signaling both play pivotal roles in the pathogenesis of heart failure. This study demonstrates that aldosterone exerts biphasic activity on insulin signaling in cardiomyocytes. While the latter is detrimental through mineralocorticoid receptor pathway, the former is protective pathway through the transient acceleration of glucose metabolism. The present data indicate that there may be a physiological role of aldosterone synthesis activated in heart failure.

Research Products

• [Journal Article] レニン-アンジオテンシン-アルドステロン系(Renin-Angiotensin-Aldosterone System ; RAAS)抑制薬-選択的アルドステロンブロッカー( エプレレノン)- (2010)
  • Author(s): 名越智古、吉村道博
  • Journal Title: Endocrinology, Diabetology & Metabolism 31(1) Pages: 41-48
• [Journal Article] レニン-アンジオテンシン-アルドステロン系(Renin-Angiotensin-Aldosterone System;RAAS)抑制薬-選択的アルドステロンブロッカー(エプレレノン)- (2010)
  • Author(s): 名越智古、吉村道博
  • Journal Title: Endocrinology, Diabetology & Metabolism Volume: 31 Pages: 41-48
• [Journal Article] 抗アルドステロン薬 (2009)
  • Author(s): 名越智古、吉村道博
  • Journal Title: Medicina 46 Pages: 39-41
• [Journal Article] 心不全と選択的アルドステロン拮抗薬 (2009)
  • Author(s): 名越智古、吉村道博
  • Journal Title: The Journal of Adult Diseases 38 Pages: 1379-1385
• [Journal Article]
  • Author(s): 名越智古、吉村道博
  • Journal Title: EMPHASIS-HF試験Cardiac Practice 2011 in press.
• [Journal Article] 心不全と抗アルドステロン薬
  • Author(s): 名越智古、吉村道博
  • Journal Title: Circulation Up-to-Date. in press.
• [Presentation] Physiological and pathophysiological effects of aldosterone on cardiomyocytes through a dynamic regulation of insulin signaling. (2010)
  • Author(s): Tomohisa Nagoshi
  • Organizer: ISHR
  • Place of Presentation: 京都
  • Year and Date: 2010-05-14
• [Presentation] Physiological and pathophysiological effects of aldosterone on cardiomyocytes through a dynamic regulation of insulin signaling (2010)
  • Author(s): Tomohisa Nagoshi
  • Organizer: International Society for Heart Research
  • Place of Presentation: 京都
  • Year and Date: 2010-05-13
• [Presentation] Aldosterone Dynamically Regulates Insulin Signaling and Exerts Cardioprotective Effects via Non-genomic Manner. (2010)
  • Author(s): Tomohisa Nagoshi
  • Organizer: 日本循環器病学会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Presentation] Aldosterone Dynamically Regulates Insulin Signaling and Exerts Cardioprotective Effects via Non-genomic Manner. (2010)
  • Author(s): Tomohisa Nagoshi
  • Organizer: Japanese Circulation Society
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Presentation] Non-genomic and Protective Effects of Aldosterone on Cardiomyocytes Through a Transient Activation of Insulin Signaling. (2009)
  • Author(s): Tomohisa Nagoshi
  • Organizer: 高血圧と冠動脈疾患研究会研究奨励賞受賞
  • Place of Presentation: 東京
  • Year and Date: 2009-12-26
• [Presentation] アルドステロンは一過性にインスリンシグナルを活性化させ、心保護作用を発揮する (2009)
  • Author(s): 名越智古
  • Organizer: 高血圧と冠動脈疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-12-26
• [Presentation] Non-genomic and Protective Effects of Aldosterone on Cardiomyocytes Through a Transient Activation of Insulin Signaling. (2009)
  • Author(s): Tomohisa Nagoshi
  • Organizer: American Heart Association
  • Place of Presentation: Orlando, U.S.A.
  • Year and Date: 2009-11-17
• [Presentation] Non-genomic and Protective Effects of Aldosterone on Cardiomyocytes Through a Transient Activation of Insulin Signaling. (2009)
  • Author(s): Tomohisa Nagoshi
  • Organizer: American Heart Association
  • Place of Presentation: Orlando,U.S.A.
  • Year and Date: 2009-11-17
• [Presentation] Non-genomic and Protective Effects of Aldosterone on Cardiomyocytes Through a Transient Activation of Insulin Signaling. (2009)
  • Author(s): Tomohisa Nagoshi
  • Organizer: Molecular Cardiovascular Conference
  • Place of Presentation: 小樽
  • Year and Date: 2009-09-05
• [Presentation] 心臓におけるAkt持続的過剰発現の病態生理学的意義 (2009)
  • Author(s): 名越智古
  • Organizer: 第15回成人病の病因・病態の解明に関する研究会
  • Place of Presentation: 軽井沢
  • Year and Date: 2009-07-04
• [Book] 原発性アルドステロン症診療マニュアル(心臓アルドステロン合成系) (2011)
  • Author(s): 名越智古、吉村道博
  • Publisher: 診断と治療社
• [Book] 高血圧診療ハンドブック(合併症を考慮した薬物療法) (2009)
  • Author(s): 名越智古、吉村道博
  • Publisher: 羊土社
• [Remarks] ホームページ等なし