Physiological and pathophysiological effects of aldosterone on cardiomyocytes through a dynamic regulation of insulin signaling.
| Project/Area Number |
21790753
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
NAGOSHI Tomohisa Jikei University School of Medicine, 医学部, 助教 (60408432)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | アルドステロン / インスリンシグナル / 心筋細胞 / 糖代謝 |
|---|
| Research Abstract |
Aldosterone and insulin signaling both play pivotal roles in the pathogenesis of heart failure. This study demonstrates that aldosterone exerts biphasic activity on insulin signaling in cardiomyocytes. While the latter is detrimental through mineralocorticoid receptor pathway, the former is protective pathway through the transient acceleration of glucose metabolism. The present data indicate that there may be a physiological role of aldosterone synthesis activated in heart failure.
|
Report
(3 results)
Research Products
(19 results)
-
-
-
-
-
[Journal Article]
Author(s)
名越智古、吉村道博
-
Journal Title
EMPHASIS-HF試験Cardiac Practice 2011 in press.
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
