The explore of the underlying molecular mechanisms of cardiac repair in cell sheet transplantation-mediated improvement of cardiac function
| Project/Area Number |
21790754
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
MATSUURA Katsuhisa Tokyo Women's Medical University, 医学部, 講師 (70433993)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 細胞シート / 心筋前駆細胞 / パラクライン効果 / 細胞シート移植 / パラクリン効果 / VCAM-1 / インテグリン |
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| Research Abstract |
When cardiac Sca-1 positive cells were isolated from the adult murine heart and were transplanted to infarcted heart as cell sheet, significant improvement of cardiac function was observed. Soluble form of VCAM-1 secreted from Sca-1 positive cells enhanced angiogenesis, cardioprotection, and migration of Sca-1 positive cells, which contributed to the improvement of cardiac function after cell sheet transplantation.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice.2009
Author(s)
Matsuura K, Honda A, Nagai T, Fukushima N, Iwanaga K, Tokunaga M, Shimizu T, Okano T, Kasanuki H, Hagiwara N, Komuro I.
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Journal Title
J Clin Invest. 119
Pages: 2204-2217
Related Report
Peer Reviewed
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