| Project/Area Number |
21790757
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
YAMAHARA Kenichi 独立行政法人国立循環器病研究センター, 再生医療部, 室長 (50450888)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOH Hiroshi 慶應義塾大学, 医学部・腎臓内分泌代謝内科, 教授 (40252457)
HOMMA Koichiro 慶応義塾大学, 医学部・腎臓内分泌代謝内科, 助教
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ES細胞 / マイクロRNA(miRNA) / 血管内皮細胞 / 血管平滑筋細胞 / 血管前駆細胞 / iPS細胞 / EPC(内皮前駆細胞) / マイクロアレイ |
|---|
| Research Abstract |
We examined the therapeutic potential of ES cell-derived vascular progenitor cells as the alternative of bone marrow-derived vascular progenitor cells. Although human ES cell-derived vascular smooth muscle cells (VSMCs) obtained by our original method were at a rather immature state of differentiation, induction of miR-145 resulted in fully differentiated VSMCs. We also found that human ES-derived VSMCs at early passage possessed high proliferation and migration property, which might be a suitable cell source for vascular regeneration.
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