Regulation of fibrotic process and dynamics of caveolae by oxidized lipid
| Project/Area Number |
21790762
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
HISATA Shu Tohoku University, 高等教育開発推進センター, 助教 (60466571)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 線維化 / 脂質 / 酸化 / 核内受容体 / 肝臓X受容体 / 脂質代謝 / 肺線維化 / カベオリン |
|---|
| Research Abstract |
We first showd that natural and synthetic ligands for Live X receptors (LXRs) have anti-fibrotic effects in human lung fibroblast. LXR agonists showed anti-fibrotic effects independently of peroxisome proliferator-activated receptor (PPAR)-γ. LXR agonists did not inhibit Smad2/3 phosphorylation and nuclear transport. LXR agonists have novel and potent anti-fibrotic effects in human lung fibroblasts.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Gradual Increase of HighMobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis.2011
Author(s)
Ebina M, Taniguchi H, Miyasho T, Yamada S, Shibata N, Ohta H, Hisata S, Ohkouchi S, Tamada T, Nishimura H, Ishizaka A, Maruyama I, Okada Y, Takashi K, Nukiwa T.
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Journal Title
Pulmonary Medicine on line
URL
Related Report
Peer Reviewed
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[Journal Article] Gradual Increase of HighMobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis.2011
Author(s)
Ebina M, Taniguchi H, Miyasho T, Yamada S, Shibata N, Ohta H, Hisata S, Ohkouchi S, Tamada T, Nishimura H, Ishizaka A, Maruyama I, Okada Y, Takashi K, Nukiwa T
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Journal Title
Pulmonary Medicine
Volume: (on line)
Related Report
Peer Reviewed
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