Regulation of fibrotic process and dynamics of caveolae by oxidized lipid

• Project/Area Number: 21790762
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: HISATA Shu Tohoku University, 高等教育開発推進センター, 助教 (60466571)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 線維化 / 脂質 / 酸化 / 核内受容体 / 肝臓X受容体 / 脂質代謝 / 肺線維化 / カベオリン

Research Abstract

We first showd that natural and synthetic ligands for Live X receptors (LXRs) have anti-fibrotic effects in human lung fibroblast. LXR agonists showed anti-fibrotic effects independently of peroxisome proliferator-activated receptor (PPAR)-γ. LXR agonists did not inhibit Smad2/3 phosphorylation and nuclear transport. LXR agonists have novel and potent anti-fibrotic effects in human lung fibroblasts.

Research Products

• [Journal Article] Gradual Increase of HighMobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis. (2011)
  • Author(s): Ebina M, Taniguchi H, Miyasho T, Yamada S, Shibata N, Ohta H, Hisata S, Ohkouchi S, Tamada T, Nishimura H, Ishizaka A, Maruyama I, Okada Y, Takashi K, Nukiwa T.
  • Journal Title: Pulmonary Medicine on line
  • URL: http://www.hindawi.com/journals/pm/
  • Peer Reviewed
• [Journal Article] A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography. (2011)
  • Author(s): Hisata S, Kimura Y, Shibata N, Ono S, Kobayashi T, Chiba S, Ohta H, Nukiwa T, Ebina M.
  • Journal Title: Pulmonary Medicine on line
  • NAID: 120003072910
  • URL: http://www.hindawi.com/journals/pm/
  • Peer Reviewed
• [Journal Article] Gradual Increase of HighMobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis. (2011)
  • Author(s): Ebina M, Taniguchi H, Miyasho T, Yamada S, Shibata N, Ohta H, Hisata S, Ohkouchi S, Tamada T, Nishimura H, Ishizaka A, Maruyama I, Okada Y, Takashi K, Nukiwa T
  • Journal Title: Pulmonary Medicine Volume: (on line)
  • Peer Reviewed
• [Journal Article] A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography. (2011)
  • Author(s): Hisata S, Kimura Y, Shibata N, Ono S, Kobayashi T, Chiba S, Ohta. H, Nukiwa T, Ebina M
  • Journal Title: Pulmonary Medicine Volume: (On line)
  • NAID: 120003072910
  • Peer Reviewed
• [Journal Article] The disappearance of subpleural and interlobular lymphatics in idiopathic pulmonary fibrosis. (2010)
  • Author(s): Ebina M, Shibata N, Ohta H, Hisata S, Tamada T, Ono M, Okaya K, Kondo T, Nukiwa T.
  • Journal Title: Lymphatic Research and Biology 8(4) Pages: 199-207
  • Peer Reviewed
• [Journal Article] The disappearance of subpleural and interlobular lymphatics in idiopathic pulmonary fibrosis. (2010)
  • Author(s): Ebina M, Shibata N, Ohta H, Hisata S, Tamada T, Ono M, Okaya K, Kondo T, Nukiwa T.
  • Journal Title: Lymphatic Research and Biology Volume: 8(4) Pages: 199-207
  • Peer Reviewed
• [Presentation] びまん性に血管気管支束周囲に浸潤影を認めた一例 (2011)
  • Author(s): 久田修、椎原淳、東條裕、海老名雅仁、貫和敏博
  • Organizer: 第3回呼吸器病態学セミナー
  • Place of Presentation: 仙台
  • Year and Date: 2011-02-22
• [Presentation] 労作時呼吸困難を呈するシェーグレン症候群の一例 (2011)
  • Author(s): 久田修、阿部恭子、玉田勉、海老名雅仁、貫和敏博
  • Organizer: 第12回膠原病肺疾患研究会
  • Place of Presentation: 仙台
  • Year and Date: 2011-02-05
• [Presentation] 抗原隔離後も進行したゼオライトによる肺傷害の一例 (2010)
  • Author(s): 久田修、阿部恭子、玉田勉、福原達郎、海老名雅仁、貫和敏博
  • Organizer: 第12回東北びまん性肺疾患研究会
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-20
• [Presentation] A normal range of KL-6/MUC1 independent of elevated SP-D indicates a better prognosis in idiopathic pulmonary fibrosis. (2010)
  • Author(s): Shu HISATA, Yuichiro KIMURA, Shuichi ONO, Makoto KOBAYASHI, Toshihiro NUKIWA, Masahito EBINA.
  • Organizer: European Respiratory Society
  • Place of Presentation: バルセロナ(スペイン)
  • Year and Date: 2010-09-22
• [Presentation] A normal range of KL-6/MUC1 independent of elevated SP-D indicates a better prognosis in idiopathic pulmonary fibrosis (2010)
  • Author(s): Shu HISATA, Yuichiro KIMURA, Shuichi ONO, Makoto KOBAYASHI, Toshihiro NUKIWA, Masahito EBINA
  • Organizer: European Respiratory Society
  • Place of Presentation: バルセロナ(スペイン)
  • Year and Date: 2010-09-22
• [Presentation] KL-6は胸部網状陰影の予後予測に有用である (2010)
  • Author(s): 久田修、海老名雅仁、貫和敏博
  • Organizer: 第1回びまん性肺疾患バイオマーカー研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-20
• [Presentation] Elevation of serum level of SP-D with normal range of KL-6 predicts a good prognosis of patients with honeycomb lesions on HRCT. (2010)
  • Author(s): Shu HISATA, Yuichiro KIMURA, Shigeki CHIBA, Kyouko ABE, Hiromitsu OHTA, Toshihiro NUKIWA, Masahito EBINA.
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: ニューオリンズ(USA)
  • Year and Date: 2010-05-17
• [Presentation] 視野欠損で発見されゲフィチニブが著効した肺癌の一例 (2010)
  • Author(s): 久田修、中村雅彦、阿部恭子、玉田勉、海老名雅仁、貫和敏博
  • Organizer: 第190回内科学会地方会
  • Place of Presentation: 仙台
  • Year and Date: 2010-02-20
• [Presentation] Elevation of serum surfactant protein D (SP-D) level predicts the early stage of honeycomb lesions on HRCT (2009)
  • Author(s): Shu HISATA, Yuichiro KIMURA, Toshihiro NUKIWA, Masahito EBINA
  • Organizer: APSR
  • Place of Presentation: 韓国(ソウル)
  • Year and Date: 2009-11-16
• [Presentation] 早期診断と生存期間の予測からみた血清バイオマーカーSP-DとKL-6の有用性と限界 (2009)
  • Author(s): 久田修、海老名雅仁、千葉茂樹、阿部恭子、木村雄一郎、谷口博之、太田洋充、大河内眞也、貫和敏博
  • Organizer: 第80回間質性肺疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-06
• [Presentation] 著明な咳嗽を主訴にGGOを指摘された一症例 (2009)
  • Author(s): 久田修、阿部恭子、玉田勉、海老名雅仁、貫和敏博
  • Organizer: 第10回東京びまん性肺疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] 人工弁機能不全と肺のすりガラス影との関連が疑われた一例 (2009)
  • Author(s): 久田修、福原達朗、中村敦、海老名雅仁、貫和敏博
  • Organizer: 第89回呼吸器学会
  • Place of Presentation: 福島
  • Year and Date: 2009-09-12
• [Presentation] 意識消失で発見されたSIADH合併肺小細胞癌の1例 (2009)
  • Author(s): 森戸正顕、久田修、阿部恭子、玉田勉、井上彰、海老名雅仁、貫和敏博
  • Organizer: 第48回日本肺癌学会東北支部会
  • Place of Presentation: 郡山
  • Year and Date: 2009-08-01
• [Presentation] 季節性気管支喘息から急速に進行したChurg-Strauss症候群の一例 (2009)
  • Author(s): 久田修、玉田勉、海老名雅仁、石井智徳、貫和敏博
  • Organizer: 第9回膠原病肺研究会
  • Place of Presentation: 仙台
  • Year and Date: 2009-07-11
• [Book] 間質性肺疾患診療マニュアル(わが国のガイドライン) (2010)
  • Author(s): 久田修、貫和敏博
  • Publisher: 南江堂
• [Book] 特発性肺線維症の急性増悪、ICUとCCU34(1) (2010)
  • Author(s): 久田修、貫和敏博
• [Book] コンセンサス癌治療(分子標的薬と薬剤性肺障害)9 (2009)
  • Author(s): 久田修、貫和敏博
• [Book] 総合臨床(間質性肺炎の臨床経過)58(4) (2009)
  • Author(s): 久田修、海老名雅仁、貫和敏博
• [Book] 病気と薬パーフェクトBOOK2011(膠原病に伴う肺疾患)
  • Author(s): 久田修、貫和敏博
  • Publisher: 南山堂
• [Remarks] ホームページ等