Antimicrobial peptides, defensin, in inflammatory diseases
| Project/Area Number |
21790766
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMAGUCHI Yasuhiro The University of Tokyo, 医学部附属病院, 講師 (60376473)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 免疫学 / 応用動物 / 微生物 / 低体重 / 肺癌 / 急性肺損傷 / defensin / 肺気腫 |
|---|
| Research Abstract |
Human・-defensin-3 and its mouse homologue, mouse・-defensin-14, showed potent cytotoxicity to mammalian cancer cells compared to other defensin isoforms. After implanting LLC adenocarcinoma in C57BL6 mice, we continuously injected mBD-14 peptide into the subcutaneous tissues around the tumor. The growth of tumor was significantly inhibited by mBD-14 peptide. In addition, the growth of LLC adenocarcinoma was significantly promoted in mBD-14-deficient mice 7 days after the implantation.
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Report
(3 results)
Research Products
(6 results)
