The effect of maternal immunity on the onset of infant asthma.
| Project/Area Number |
21790769
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
KOBAYASHI Kazuyuki Kobe University, 大学院・医学研究科, 助教 (50403275)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 母子垂直伝搬 / 免疫グロブリン / FcRn / 気管支喘息 / 母子垂直伝播 / 抗原特異的IgG / アレルギー感受性 / Fcレセプター / 母子間 |
|---|
| Research Abstract |
By sensitizing mother before pregnancy and inducing allergic airway inflammation during pregnancy, serum OVA-specific IgE level and sensitivity for asthma was significantly reduced in wild-type offspring. It was assumed that maternal passive immunity by the transportation of antigen specific IgG may regulate allergic airway inflammation. The administration of antigen specific IgG into mother mice during lactating period reduced airway inflammation of offspring in wild type mice, but not in FcRn deficient mice. It is concluded that he transfer of maternal antigen-specific IgG regulates the development of allergic airway inflammation early in life in the FcRn-dependent manner.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] The inhibitory effects of intravenous administration of rabbit immunoglobulin G on airway inflammation are dependent upon Fcy receptor IIb on CD11c(+) dendritic cells in a murine model.2010
Author(s)
Yamamoto M, Kobayashi K, Ishikawa Y, Nakata K, Funada Y, Kotani Y, Masuda A, Takai T, Azuma T, Yoshida M, Nishimura Y.
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Journal Title
Clin Exp Immunol. 162(2)
Pages: 315-24
Related Report
Peer Reviewed
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