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Analysis of Severe Influenza Pneumonia -Control of Host and Pathogen Factors in Influenza and Bacteria Co-infected Mice Models

Research Project

Project/Area Number 21790774
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionNagasaki University

Principal Investigator

SEKI Masafumi  Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (80432970)

Co-Investigator(Kenkyū-buntansha) KOHNO Shigeru  長崎大学, 大学院・医歯薬学総合研究科, 助教 (80136647)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsインフルエンザ / 細菌感染 / 肺炎 / 新規抗インフルエンザ薬 / ペラミビル
Research Abstract

We examined the mechanisms of severe influenza virus-related pneumonia. In pathogens factor, quorum sensing related genes were deleted in Pseudomonas, and we infected them to mice. Toxin were decreased, but no significant differences were found in vivo. However, apoptosis were detected in virus and Streptococcus co-infected mice, and excessive inflammation and pulmonary edema according to cytokine storm were observed in TLR-related genes-deleted mice by influenza virus infection alone. Excessive inflammation might be related to progression of severe pneumonia

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (43 results)

All 2010 2009 Other

All Journal Article (29 results) (of which Peer Reviewed: 3 results) Presentation (8 results) Book (2 results) Remarks (4 results)

  • [Journal Article] Critical role of IRAK-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia.2010

    • Author(s)
      Seki M, Kohno S, Newstead M, Zeng X, Bhan U, Lukacs N, Kunkel S, Standiford T.
    • Journal Title

      J Immunol. 184

      Pages: 1410-1418

    • Related Report
      2010 Final Research Report
  • [Journal Article] A case of intravascular large B-cell lymphoma(IVLBCL)with no abnormal findings on chest computed tomography diagnosed by random transbronchial lung biopsy.2010

    • Author(s)
      Kaku N, Seki M, Doi S, Hayashi T, Imanishi D, Imamura Y, Kurihara S, Miyazaki T, Izumikawa K, Kakeya H, Yamamoto Y, Yanagihara K, Tashiro T, Kohno S.
    • Journal Title

      Intern Med. 49

      Pages: 2697-2701

    • NAID

      130000413430

    • Related Report
      2010 Final Research Report
  • [Journal Article] for the S-021812 Clinical Study Group.Efficacy and safety of intravenous peramivir for the treatment of seasonal influenza.2010

    • Author(s)
      Kohno S, Kida H, Mizuguchi M, Shimada J
    • Journal Title

      Antimicrob Agents Chemother 54

      Pages: 4568-4574

    • Related Report
      2010 Final Research Report
  • [Journal Article] Legionella pneumophila Induces Cathepsin B-dependent Necrotic Cell Death with Releasing High Mobility Group Box1 in Macrophages.2010

    • Author(s)
      Morinaga Y, Yanagihara K, Nakamura S, Hasegawa H, Seki M, Izumikawa K, Kakeya H, Yamamoto Y, Yamada Y, Kohno S, Kamihira S.
    • Journal Title

      Respir Res. 22;11

      Pages: 158-158

    • Related Report
      2010 Final Research Report
  • [Journal Article] Importance of Controlling Drug-resistant Pseudomonas aeruginosa Infection: Experience from Lung Transplantation in a Cystic Fibrosis Case.2010

    • Author(s)
      Yamamoto Y, Izumikawa K, Hara A, Fujita H, Amenomori M, Sakamoto N, Seki M, Kakeya H, Yanagihara K, Takasaki K, Miyazaki T, Tsuchiya T, Yamasaki N, Tagawa T, Nagayasu T, Kohno S.
    • Journal Title

      Intern Med. 49

      Pages: 2353-2358

    • NAID

      130000413356

    • Related Report
      2010 Final Research Report
  • [Journal Article] In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.2010

    • Author(s)
      Morinaga Y, Yanagihara K, Araki N, Yamada K, Seki M, Izumikawa K, Kakeya H, Yamamoto Y, Yamada Y, Kohno S, Kamihira S.
    • Journal Title

      Exp Lung Res. 36

      Pages: 484-490

    • NAID

      120006984903

    • Related Report
      2010 Final Research Report
  • [Journal Article] Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit.2010

    • Author(s)
      Yanagihara K, Kitagawa Y, Tomonaga M, Tsukasaki K, Kohno S, Seki M, Sugimoto H, Shimazu T, Tasaki O, Matsushima A, Ikeda Y, Okamoto S, Aikawa N, Hori S, Obara H, Ishizaka A, Hasegawa N, Takeda J, Kamihira S, Sugahara K, Asari S, Murata M, Kobayashi Y, Ginba H, Sumiyama Y, Kitajima M.
    • Journal Title

      Crit Care. 14

    • Related Report
      2010 Final Research Report
  • [Journal Article] Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata.2010

    • Author(s)
      Miyazaki T, Yamauchi S, Inamine T, Nagayoshi Y, Saijo T, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Miyazaki Y, Kohno S.
    • Journal Title

      Antimicrob Agents Chemother. 54

      Pages: 1639-1643

    • NAID

      120006984565

    • Related Report
      2010 Final Research Report
  • [Journal Article] Diffuse Alveolar Hemorrhage following Itraconazole Injection.2010

    • Author(s)
      Izumikawa K, Nakano K, Kurihara S, Imamura Y, Yamamoto K, Miyazaki T, Sakamoto N, Seki M, Ishimatsu Y, Kakeya H, Yamamoto Y, Yanagihara K, Tsuchiya T, Yamasaki N, Tagawa T, Mukae H, Nagayasu T, Kohno S.
    • Journal Title

      Intern Med. 49

      Pages: 497-500

    • NAID

      130000251704

    • Related Report
      2010 Final Research Report
  • [Journal Article] Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata.2010

    • Author(s)
      Miyazaki T, Inamine T, Yamauchi S, Nagayoshi Y, Saijo T, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Miyazaki Y, Kohno S.
    • Journal Title

      FEMS Yeast Res. 10

      Pages: 343-352

    • NAID

      120006984540

    • Related Report
      2010 Final Research Report
  • [Journal Article] Skn7p Is Involved in Oxidative Stress Response and Virulence of Candida glabrata.2010

    • Author(s)
      Saijo T, Miyazaki T, Izumikawa K, Mihara T, Takazono T, Kosai K, Imamura Y, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Kohno S.
    • Journal Title

      Mycopathologia. 169

      Pages: 81-90

    • Related Report
      2010 Final Research Report
  • [Journal Article] Efficacy of clarithromycin against experimentally induced pneumonia caused by clarithromycin-resistant Haemophilus influenzae in mice.2010

    • Author(s)
      Nakamura S, Yanagihara K, Araki N, Yamada K, Morinaga Y, Izumikawa K, Seki M, Kakeya H, Yamamoto Y, Kamihira S, Kohno S.
    • Journal Title

      Antimicrob Agents Chemother. 54

      Pages: 757-762

    • NAID

      120006984671

    • Related Report
      2010 Final Research Report
  • [Journal Article] 平成21年度北里柴三郎記念学術奨励賞受賞記念論文インフルエンザ関連肺炎の重症化機序の解析と治療法の検討2010

    • Author(s)
      関雅文、田中章貴、小佐井康介、河野茂
    • Journal Title

      日本感染症学会雑誌 84

      Pages: 689-693

    • Related Report
      2010 Final Research Report
  • [Journal Article] 私達の研究インフルエンザウイルス肺炎と細菌感染の合併による重症化機序2010

    • Author(s)
      関雅文、小佐井康介、田中章貴、河野茂
    • Journal Title

      化学療法の領域 26

      Pages: 2460-2466

    • Related Report
      2010 Final Research Report
  • [Journal Article] 話題のくすり ペラミビル水和物2010

    • Author(s)
      関雅文、河野茂
    • Journal Title

      日本病院薬剤師会雑誌 46

      Pages: 1553-1555

    • Related Report
      2010 Final Research Report
  • [Journal Article] 一日一回投与時代の抗菌化学療-新規抗インフルエンザ薬の新たな展開2010

    • Author(s)
      関雅文、河野茂
    • Journal Title

      化学療法の領域 26

      Pages: 1425-1430

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新型インフルエンザの病態の特徴-季節性インフルエンザと比較して2010

    • Author(s)
      関雅文、河野茂
    • Journal Title

      呼吸器科 17

      Pages: 24-28

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新型インフルエンザの出現と対策2010

    • Author(s)
      河野茂、関雅文
    • Journal Title

      呼吸器科 17

      Pages: 1-5

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新しい抗インフルエンザ薬2010

    • Author(s)
      関雅文、河野茂
    • Journal Title

      日内誌 11

      Pages: 2735-2739

    • NAID

      10027509089

    • Related Report
      2010 Final Research Report
  • [Journal Article] ペラミビル2010

    • Author(s)
      河野茂、関雅文
    • Journal Title

      インフルエンザ 11

      Pages: 360-364

    • Related Report
      2010 Final Research Report
  • [Journal Article] ペラミビル2010

    • Author(s)
      河野茂、関雅文
    • Journal Title

      臨床と微生物 10

      Pages: 549-552

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新規治療薬の展望1)抗インフルエンザ薬2010

    • Author(s)
      関雅文、河野茂
    • Journal Title

      感染と抗菌薬 13

      Pages: 372-376

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新しい抗インフルエンザ薬2010

    • Author(s)
      田中章貴、関雅文、小佐井康介、河野茂
    • Journal Title

      ペラミビル 臨床と研究 87

      Pages: 1702-1706

    • NAID

      10027509089

    • Related Report
      2010 Final Research Report
  • [Journal Article] Critical role of IRAK-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia.2010

    • Author(s)
      Seki M, Kohno S, Newstead M, Zeng X, Bhan U, Lukacs N, Kunkel S, Standiford T.
    • Journal Title

      J Immunol

      Volume: 184 Pages: 1410-1418

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新しい抗インフルエンザ薬2010

    • Author(s)
      関雅文、河野茂
    • Journal Title

      日本内科学会雑誌

      Volume: 99 Pages: 2735-2739

    • NAID

      10027509089

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 平成21年度北里柴三郎記念学術奨励賞受賞記念論文インフルエンザ関連肺炎の重症化機序の解析と治療法の検討2010

    • Author(s)
      関雅文、田中章貴、小佐井康介、河野茂
    • Journal Title

      日本感染症学会雑誌

      Volume: 84 Pages: 689-693

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Critical role of IRAK-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia.2010

    • Author(s)
      Seki M, Kohno S, Newstead M, et al.
    • Journal Title

      J.Immunol. 184

      Pages: 1410-1418

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and analysis of Platelet activating factor (PAF) related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection using by DNA microarray2009

    • Author(s)
      Seki M, Kosai K, Hara A, et al.
    • Journal Title

      Jpn J Infect Dis. 62

      Pages: 6-10

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 院内肺炎ガイドライン20082009

    • Author(s)
      関雅文、河野茂
    • Journal Title

      呼吸 28

      Pages: 715-719

    • Related Report
      2009 Annual Research Report
  • [Presentation] Critical Role of IRAK-M in Regulating Chemokine-dependent Deleterious Inflammation in Murine Influenza Pneumonia2010

    • Author(s)
      関雅文
    • Organizer
      American Thoracic Society(米国胸部学会)
    • Place of Presentation
      米国:ニューオリンズ(口頭発表演題)
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] ランチョンセミナー最新の抗インフルエンザ薬とガイドラインに沿った呼吸器感染症診療2010

    • Author(s)
      関雅文
    • Organizer
      第25回環境感染学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] ミニシンポジウムノックアウトマウスを用いた重症インフルエンザ肺炎の発症機序の解析2010

    • Author(s)
      関雅文、小佐井康介、田中章貴、河野茂
    • Organizer
      第84回日本感染症学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] English Mini Symposium Critical Role of IRAK-M in Regulating Chemokine-dependent Deleterious Inflammation in Murine Influenza Pneumonia2010

    • Author(s)
      Seki M, etal.
    • Organizer
      第50回日本呼吸器学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Mini Symposium (Oral presentation) Critical Role of IRAK-M in Regulating Chemokine-dependent Deleterious Inflammation in Murine Influenza Pneumonia2010

    • Author(s)
      Seki M, Kohno S, etal.
    • Organizer
      ATS(米国胸部疾患学会)
    • Place of Presentation
      ニューオーリンズ
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウムインフルエンザに合併する重症インフルエンザの発症機序の解析2010

    • Author(s)
      関雅文
    • Organizer
      第58回日本化学療法学会総会
    • Place of Presentation
      長崎
    • Related Report
      2010 Final Research Report
  • [Presentation] 大分イブニングシンポジウム語ろう日本の新型インフルエンザ新しい抗インフルエンザ薬と今後のインフルエンザ診療2010

    • Author(s)
      関雅文
    • Organizer
      西日本化学療法学会
    • Related Report
      2010 Final Research Report
  • [Presentation] Proteomic analysis and protease inhibitor therapy for influenza-related pneumonia2009

    • Author(s)
      Seki M, Tanaka A, Kosai K, et al.
    • Organizer
      国際化学療法学会(ISC)
    • Place of Presentation
      トロント(カナダ)
    • Year and Date
      2009-06-19
    • Related Report
      2009 Annual Research Report
  • [Book] VI基礎疾患(糖尿病・喘息・COPD)を持つ患者への対応これでわかるインフルエンザ診療のポイント(藤田次郎編)2010

    • Author(s)
      関雅文、河野茂
    • Publisher
      南江堂(東京)
    • Related Report
      2010 Final Research Report
  • [Book] これでわかるインフルエンザ診療のポイントVI基礎疾患(糖尿病・喘息・COPD)を持つ患者への対応2010

    • Author(s)
      関雅文、河野茂
    • Total Pages
      7
    • Publisher
      南江堂(東京)
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/intmed-2/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/mmi/mcm/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/intmed-2/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagasaki-u.ac.jp/mmi/mcm/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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