| Project/Area Number |
21790776
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
ONO Chiaki Sapporo Medical University, 医学部, 助教 (30381255)
|
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 肺サーファクタント / トル様受容体(TLR) / 酸化肺サーファクタント脂質 / リポ多糖(LPS) / 炎症応答 / LPS / 肺サーファクタント脂質 / トル様受容体 / コレクチン / 肺サーファクタント蛋白質 / 自然免疫 / マクロファージ |
|---|
| Research Abstract |
In this study, we demonstrated that oxidized surfactant lipids (oxSLs) and oxidized PAPC (1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine) inhibit LPS-induced inflammatory responses by different mechanisms. Because the generation of reactive oxygen species is one of the characteristics of inflammation that results in the oxidation of host lipids, oxSLs may contribute to reduce the excessive inflammatory response to LPS.
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