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Adipocytokine as an exacerbation factor for asthma and its possible involvement in therapeutic target for asthma

Research Project

Project/Area Number 21790779
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionOsaka City University

Principal Investigator

ASAI Kazuhisa  Osaka City University, 大学院・医学研究科, 研究員 (10382053)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords閉塞性肺疾患 / 気管支喘息 / 肥満 / アディポサイトカイン / アレルギー・喘息 / 免疫学 / メタボリックシンドローム
Research Abstract

We recruited 25 obesity asthma(BMI≧25,n=5) and non-obesityasthma(BMI<25,n=16). We examined asthma severity in dices such as %FEV1, PC20, FeNO and adiponectin and leptin concentrations in plasma and induced sputum supernatant in all asthmatic patients. Although there were significant correlations between adipocytokine concentrations and BMI in asthmatic patients, there were not significant correlations between adipocytokine concentrations and asthma severity indices.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 2009 Other

All Journal Article (19 results) (of which Peer Reviewed: 8 results) Presentation (4 results) Book (2 results)

  • [Journal Article] Potential roles of pentosidine in age-related and disease-related impairment of pulmonary functions in patients with asthma.2011

    • Author(s)
      Kanazawa H, Tochino Y, Kyoh S, Ichimaru Y, Asai K, Hirata K.
    • Journal Title

      J Allergy Clin Immunol. (in press).

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased levels of HMGB-1 and endogenous secretory RAGE in induced sputum from asthmatic patients.2011

    • Author(s)
      Watanabe T, Asai K, Fujimoto H, Tanaka H, Kanazawa H, Hirata K.
    • Journal Title

      Respir Med. 105(4)

      Pages: 519-25

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased levels of HMGB-1 and endogenous secretory RAGE in induced sputum from asthmatic patients.2011

    • Author(s)
      Watanabe T, Asai K, Fujimoto H, Tanaka H, Kanazawa H, Hirata K
    • Journal Title

      Respiratory Medicine

      Volume: 105 Pages: 519-25

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 喘息とCOPDをめぐって類似点と相違点2010

    • Author(s)
      平田一人, 浅井一久
    • Journal Title

      治療ステロイドの効果の差アレルギー・免疫 17巻12号

      Pages: 2034-2042

    • Related Report
      2010 Final Research Report
  • [Journal Article] 咳の新しい捉え方2010

    • Author(s)
      平田一人, 浅井一久
    • Journal Title

      COPD成人病と生活習慣病 40巻11号

      Pages: 1285-1290

    • Related Report
      2010 Final Research Report
  • [Journal Article] Validity of measurement of two specific biomarkers for the assessment of small airways inflammation in asthma.2010

    • Author(s)
      Kanazawa H, Kyoh S, Asai K, Hirata K.
    • Journal Title

      J Asthma. 47(4)

      Pages: 400-406

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased levels of N(epsilon)-(carboxymethyl)lysine in epithelial lining fluid from peripheral airways in patients with chronic obstructive pulmonary disease : a pilot study.2010

    • Author(s)
      Kanazawa H, Kodama T, Asai K, Matsumura S, Hirata K.
    • Journal Title

      Clin Sci (Lond). 119(3)

      Pages: 143-149

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 喫煙とCOPD2010

    • Author(s)
      平田一人, 浅井一久
    • Journal Title

      喫煙が気管支拡張薬に及ぼす影響呼吸器内科 17巻5号

      Pages: 450-455

    • Related Report
      2010 Final Research Report
  • [Journal Article] 呼吸不全の実地診療治療ストラテジーの新たな展開2010

    • Author(s)
      平田一人, 浅井一久
    • Journal Title

      呼吸不全の実地診療・セミナー/呼吸不全をきたす疾患の実地診療のポイント気管支喘息急性期から慢性期のアプローチの実際Medical Practice 27巻4

      Pages: 633-639

    • Related Report
      2010 Final Research Report
  • [Journal Article] 増加するアレルギー疾患内科医にとっての最良のアプローチとは2010

    • Author(s)
      平田一人, 浅井一久
    • Journal Title

      成人喘息への理解と対応合併病態への対応COPDと喘息の合併内科 105巻4号

      Pages: 644-649

    • Related Report
      2010 Final Research Report
  • [Journal Article] 吸入療法の新展開吸入去痰薬の新しい動向2010

    • Author(s)
      浅井一久, 平田一人
    • Journal Title

      吸入療法 2巻1号

      Pages: 74-81

    • Related Report
      2010 Final Research Report
  • [Journal Article] 呼吸不全の実地診療治療ストラテジーの新たな展開2010

    • Author(s)
      平田一人, 浅井一久
    • Journal Title

      呼吸不全の実地診療・セミナー/呼吸不全をきたす疾患の実地診療のポイント気管支喘息急性期から慢性期のアプローチの実際Medical Practice 27巻4号

      Pages: 633-639

    • Related Report
      2010 Final Research Report
  • [Journal Article] Validity of measurement of two specific biomarkers for the assessment of small airways inflammation in asthma.2010

    • Author(s)
      Kanazawa H, Kyoh S, Asai K, Hirata K
    • Journal Title

      Journal of Asthma

      Volume: 47 Pages: 400-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 末梢気道をめぐって2009

    • Author(s)
      平田一人, 浅井一久
    • Journal Title

      末梢気道障害が関与する呼吸器疾患(喘息を除く)アレルギー・免疫 17巻1号

      Pages: 30-35

    • Related Report
      2010 Final Research Report
  • [Journal Article] 最新のCOPD治療大規模臨床試験の結果から2009

    • Author(s)
      平田一人, 浅井一久
    • Journal Title

      COPDにおける早期治療介入の有用性を示したチオトロピウムの長期大規模臨床試験UPLIFT Study医学のあゆみ 231巻4号

      Pages: 271-276

    • Related Report
      2010 Final Research Report
  • [Journal Article] 咳嗽そのcommonで多様な疾患領域2009

    • Author(s)
      平田一人, 浅井一久
    • Journal Title

      咳嗽の治療綜合臨床 58巻10号

      Pages: 2067-2071

    • Related Report
      2010 Final Research Report
  • [Journal Article] Increased levels of angiopoietin-2 in induced sputum from smoking asthmatic patients.2009

    • Author(s)
      Kanazawa H, Asai K, Tochino Y, Kyoh S, Kodama T, Hirata K.
    • Journal Title

      Clin Exp Allergy. 39(9)

      Pages: 1330-1337

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential mechanisms of airway remodeling initiated by activated thrombin in asthma.2009

    • Author(s)
      Kanazawa H, Kyoh S, Tochino Y, Kodama T, Asai K, Hirata K.
    • Journal Title

      Arerugi.(Japanese.) 58(5)

      Pages: 554-559

    • NAID

      110007337983

    • Related Report
      2010 Final Research Report
  • [Journal Article] Potential roles of pentosidine in age-related and disease-related impairment of pulmonary functions in patients with asthma.

    • Author(s)
      Kanazawa H, Tochino Y, Kyoh S, Ichimaru Y, Asai K, Hirata K
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 気管支喘息におけるHigh mobility group box1 (HMGB-1)の関与についての検討2010

    • Author(s)
      渡辺徹也, 浅井一久, 小林大起, 白土直子, 藤本寛樹, 鴨井博, 金澤博, 平田一人
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Advanced glycation end products stimulate vascular endothelial growth factor production from human airway epithelial cells in vitro and in vivo.2010

    • Author(s)
      Asai K, Kanazawa H, Watanabe T, Fujimoto H, Kyoh S, Hirata K.
    • Organizer
      American Thoracic Society
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2010-05-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 終末糖化産物は気道上皮におけるVascular Endothelial Growth Factorの産生を増強する2010

    • Author(s)
      浅井一久, 金澤博, 小林大起, 白土直子, 渡辺徹也, 藤本寛樹, 児玉豊城, 松村佐恵子, 姜成勲, 鴨井博, 平田一人
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 終末糖化産物は気道上皮におけるVascular Endothlial Growth Factorの産生を増強する2010

    • Author(s)
      浅井一久, 金澤博, 小林大起, 白土直子, 渡辺徹也, 藤本寛樹, 児玉豊城, 松村佐恵子, 姜成勲, 鴨井博, 平田一人
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Book] 最新医学別冊「新しい診断と治療のABC」呼吸器2喘息(改訂第2版)(第4章管理・治療薬物療法・選択基準)2011

    • Author(s)
      浅井一久, 平田一人
    • Publisher
      (共著、印刷中)
    • Related Report
      2010 Final Research Report
  • [Book] 最新医学別冊「新しい診断と治療のABC」呼吸器2 喘息(改訂第2版)2011

    • Author(s)
      浅井一久, 平田一人
    • Publisher
      最新医学社(印刷中)
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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