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Phenotyping Patients With Obstructive Sleep Apnea and Treatment Strategy. an adoption of non-linear analysis-

Research Project

Project/Area Number 21790781
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionNara Medical University

Principal Investigator

YAMAUCHI Motoo  奈良県立医科大学, 医学部, 助教 (30405378)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords睡眠時無呼吸症候群 / 非線形解析 / 呼吸制御システム / 持続陽圧呼吸(CPAP)療法 / CPAPアドヒアランス
Research Abstract

We analyzed the respiratory time series data during wakefulness in patients with obstructive sleep apnea(OSA). Breathing irregularity evaluated by both linear and non-linear analyses in patients with mixed apnea dominant OSA was significantly greater than in patients with obstructive apnea dominant, and was similar to central sleep apnea syndrome. Moreover, breathing irregularity was a predictive marker for CPAP adherence in patients with OSA. Thus we conclude that breathing irregularity during wakefulness evaluated by both linear and non-linear analyses reflects not only an OSAS phenotype but CPAP adherence.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (19 results)

  • [Journal Article] Identification of Novel Mouse Genes Conferring Post-Hypoxic Pauses2012

    • Author(s)
      Gillombardo CB, Yamauchi M, Adams MD, Dostal J, Chai S, Moore MW, Donovan LM, Han F, Strohl KP
    • Journal Title

      J Appl Physiol

      Volume: (In press) Issue: 1 Pages: 167-174

    • DOI

      10.1152/japplphysiol.01394.2011

    • Year and Date
      2012-07-01
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in Breathing Patterning During Wakefulness in Patients With Mixed Apnea-Dominant vs Obstructive-Dominant Sleep Apnea2011

    • Author(s)
      Yamauchi M, Tamaki S, Yoshikawa M, Ohnishi Y, Nakano H, Jacono FJ, Loparo KA, Strohl KP, Kimura H
    • Journal Title

      Chest

      Volume: 140 Issue: 1 Pages: 54-61

    • DOI

      10.1378/chest.10-1082

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mouse models of apnea : strain differences in apnea expression and its pharmacologic and genetic modification2010

    • Author(s)
      Yamauchi M, Kimura H, Strohl KP
    • Journal Title

      Adv Exp Med Biol

      Volume: 669 Pages: 303-307

    • DOI

      10.1007/978-1-4419-5692-7_62

    • ISBN
      9781441956910, 9781441956927
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Mouse models of apnea : strain differences in apnea expression and its pharmacologic and genetic modification2010

    • Author(s)
      Yamauchi M, H Kimura, KP Strohl
    • Journal Title

      Adv Exp Med Biol 669

      Pages: 303-307

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Differences in Breathing Patterning during Wakefulness in Patients with Mixed-Apnea Dominant vs.Obstructive-Dominant Sleep Apnea

    • Author(s)
      Yamauchi M, Tamaki S, Yoshikawa M, Ohnishi Y, Nakano H, Jacono FJ, Loparo KA, Strohl KP, Kimura H.
    • Journal Title

      CHEST

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 『肥満低換気症候群は稀少疾患として位置づけるべきか?』-肥満度と呼吸調節機構からみたOSASとの差異-2012

    • Author(s)
      山内基雄、吉川雅則、牧之段潔、福岡篤彦、藤田幸男、児山紀子、玉置伸二、山本佳史、友田恒一、木村弘
    • Organizer
      第52回日本呼吸器学会学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 閉塞性睡眠時無呼吸症候群における覚醒時安静呼吸の不規則性とCPAPアクセプタンス2011

    • Author(s)
      山内基雄, 藤田幸男, 吉川雅則, 大西徳信, 中野博, 木村弘
    • Organizer
      第21回日本呼吸ケア・リハビリテーション学会学術集会
    • Place of Presentation
      松本
    • Year and Date
      2011-11-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 閉塞性睡眠時無呼吸症候群における覚醒時安静呼吸の不規則性とCPAPアクセプタンス2011

    • Author(s)
      山内基雄, 藤田幸男, 吉川雅則, 大西徳信, 中野博, 木村弘
    • Organizer
      第21回日本呼吸ケア・リハビリテーション学会学術集会
    • Place of Presentation
      松本、長野県
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] OSA Phenotype and Breathing Irregularity2011

    • Author(s)
      Motoo Yamauchi, Hiroshi Kimura
    • Organizer
      Sponsored symposium by Philips Respironics, Worldsleep 2011
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-10-19
    • Related Report
      2011 Final Research Report
  • [Presentation] OSA Phenotype and Breathing Irregularity2011

    • Author(s)
      Motoo Yamauchi, Hiroshi Kimura
    • Organizer
      World sleep 2011
    • Place of Presentation
      Kyoto, Japan(招待講演)
    • Year and Date
      2011-10-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] OSASの多様性と治療戦略2011

    • Author(s)
      山内基雄、木村弘
    • Organizer
      第36回日本睡眠学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2011-10-15
    • Related Report
      2011 Final Research Report
  • [Presentation] OSASの多様性と治療戦略2011

    • Author(s)
      山内基雄、木村弘
    • Organizer
      第36回日本睡眠学会学術集会
    • Place of Presentation
      京都、京都府(招待講演)
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] ストレス下睡眠が睡眠呼吸障害に及ぼす影響についての検討2011

    • Author(s)
      山内基雄、玉置伸二、吉川雅則、木村弘
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京、東京都
    • Year and Date
      2011-04-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] CPAP acceptance and resting breathing irregularity during wakefulness in obstructive sleep apnea2011

    • Author(s)
      Motoo Yamauchi, Masanori Yoshikawa, Yoshinobu Ohnishi, Hiroshi Nakano, Kingman P. Strohl, Hiroshi Kimura
    • Organizer
      The 12th Sleep and Breathing International Conference
    • Place of Presentation
      Barcelona
    • Year and Date
      2011-04-08
    • Related Report
      2011 Final Research Report
  • [Presentation] CPAP acceptance and resting breathing irregularity during wakefulness in obstructive sleep apnea2011

    • Author(s)
      Motoo Yamauchi, Masanori Yoshikawa, Yoshinobu Ohnishi, Hiroshi Nakano, Kingman P.Strohl, Hiroshi Kimura
    • Organizer
      The 12th Sleep and Breathing International Conference
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2011-04-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] CPAP acceptance予測因子としての覚醒時呼吸不規則性の可能性2010

    • Author(s)
      山内基雄, 玉置伸二, 吉川雅則, 大西徳信, 中野博, 木村弘
    • Organizer
      第35回日本睡眠学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-02
    • Related Report
      2011 Final Research Report
  • [Presentation] CPAP acceptance予測因子としての覚醒時呼吸不規則性の可能性2010

    • Author(s)
      山内基雄, 玉置伸二, 吉川雅則, 大西徳信, 中野博, 木村弘
    • Organizer
      日本睡眠学会第35回定期学術集会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2010-07-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] CPAP acceptance and resting awake breathing irregularity in obstructive sleep apnea2010

    • Author(s)
      Motoo Yamauchi, Shinji Tamaki, Masanori Yoshikawa, Yoshinobu Ohnishi, Hiroshi Nakano, Hiroshi Kimura
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2010-05-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] CPAP acceptance and resting awake breathing irregularity in obstructive sleep apnea2010

    • Author(s)
      Motoo Yamauchi, Shinji Tamaki, Masanori Yoshikawa, Yoshinobu Ohnishi, Hiroshi Nakano, Hiroshi Kimura
    • Organizer
      American Thoracic Society International Conference 2010
    • Place of Presentation
      New Orleans
    • Year and Date
      2010-05-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 混合型睡眠時無呼吸は閉塞型睡眠時無呼吸として扱ってよいか?2010

    • Author(s)
      山内基雄、玉置伸二、友田恒一、吉川雅則、大西徳信、中野博、木村弘
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 混合型睡眠時無呼吸は閉塞型睡眠時無呼吸として扱ってよいか?2010

    • Author(s)
      山内基雄、玉置伸二、友田恒一、吉川雅則、大西徳信、中野博、木村弘
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Should mixed apnea be classified with obstructive sleep apnea?2009

    • Author(s)
      Motoo Yamauchi, Shinji Tamaki, Masanori Yoshikawa, Yosbinobu Ohnishi, Hiroshi Nakano, Kingman P.Strohl, Hiroshi Kimura
    • Organizer
      ERS Annual Congress
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2009-09-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Should mixed apnea be classified with obstructive sleep apnea?2009

    • Author(s)
      Motoo Yamauchi, Kingman P. Strohl, Hiroshi Kimura
    • Organizer
      The 11th Sleep and Breathing International Conference
    • Place of Presentation
      Pittsburgh
    • Year and Date
      2009-09-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Should mixed apnea be classified with obstructive sleep apnea?2009

    • Author(s)
      Motoo Yamauchi, Kingman P.Strohl, Hiroshi Kimura
    • Organizer
      The 11th Sleep and Breathing International Conference
    • Place of Presentation
      Pittsburgh, USA
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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