Mechanisms and management of COPD exacerbations : role of toll-like receptors on the activation of neutrophil
| Project/Area Number |
21790782
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
KOARAI Akira 和歌山県立医科大学, 医学部, 助教 (80458059)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 慢性閉塞性肺疾患 / 急性増悪 / 酸化ストレス / ウイルス / toll様受容体 / ウイルス感染 / Toll-like受容体 / 好中球 / サイトカイン / NF-kB |
|---|
| Research Abstract |
In the present study, we demonstrated that one of toll like receptors, TLR8-mediated neutrophilic responses were markedly potentiated via NF-κB signaling by oxidative stress which is important in the pathophysiology of COPD. This might potentiate the neutrophilic inflammation during the viral-induced COPD exacerbations.
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Report
(4 results)
Research Products
(48 results)
