Effect of apoptotic cell phagocytosis on pulmonary emphysema
Project/Area Number |
21790787
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Respiratory organ internal medicine
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Research Institution | Keio University |
Principal Investigator |
MINEMATSU Naoto Keio University, 医学部, 講師 (20296578)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 肺気腫 / 貪食 / アポトーシス / マウス |
Research Abstract |
We applied elastase-induced mouse model to test the effect of impaired macrophage phagocytosis of apoptotic cells on pulmonary emphysema. Intra-nasal instillation of Annexin V, potent inhibitor of macrophage phagocytosis, worsened the pulmonary emphysema. Annexin V-treated mice had an increased number of alveolar macrophages, lower level of VEGF in BALF, and increased transcriptional activity of MMP genes. Collectively, impaired macrophage phagocytosis could deteriorate the pulmonary emphysema via fewer repairs and more destruction in this model.
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Report
(3 results)
Research Products
(5 results)
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[Presentation] Impaired phagocytosis deteriorates elastase-induced pulmonary emphysema in mice2010
Author(s)
S Yoshida, N Minematsu, H Nakamura, S Chubachi, K Tsuzuki, H Tateno, M Mouded, S D Shapiro, K Asano, A Ishizaka
Organizer
American Thoracic Society International Conference
Place of Presentation
New Orleans, USA
Year and Date
2010-05-17
Related Report
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