TNF induced lung injury was protected by EGFR transactivation
| Project/Area Number |
21790788
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 肺癌 / 肺障害 / 上皮成長因子受容体 / 腫瘍壊死因子 / 急性肺障害 / EGFR / TNF-alpha / apoptosis / TACE / アポトーシス / 肺線維症 |
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| Research Abstract |
EGFR tyrosine kinase activity protects TNF-induced lung epithelial cells apoptosis and this might be the mechanism of EGFR tyrosine kinase inhibitor (TKI)-induced lung injury. In this study, to the purpose of clarifying the mechanisms, we employed the SPC/TNF-transgenic mice, which over-expressed TNF in alveolar type 2 cells under the control of the human surfactant protein C promoter, resulted in interstitial pneumonia and pulmonary fibrosis chronically. EGFR-TKI, Gefitinib was orally administrated for this mice, then we observed worsened the lung injury. This novel observation has significant implications for understanding the role of EGFR in maintaining human lung epithelial cell homeostasis in an environment of inflammation, injury/repair, such as inflammation-associated carcinogenesis and cancer promotion.
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Report
(5 results)
Research Products
(16 results)
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[Presentation] Specific epidermal growth factor receptor autophosphorylation sites promote epithelial cell chemotaxis and restitution2012
Author(s)
Toshimitsu Yamaoka, Mark Frey, D. Brent Polk, Yasunari Oki, Yasunori Murata, Tomohide Sugiyama, Sojiro Kusumoto, Hiroo Ishida, Takao Shirai, Masanao Nakashima, Kentaro Okuda, Tsukasa Ohnishi, Takashi Hirose, Tohru Ohmori and Mitsuru Adachi
Organizer
103rd Annual Meeting of American Association for Cancer Research
Place of Presentation
Chicago
Related Report
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[Presentation] 気道上皮細胞と非小細胞肺癌細胞におけるTACEを介したTNFによるEGFRのトランス活性化機序の検討2012
Author(s)
山岡 利光, 村田 泰規, 大木 康成, 楠本 壮二郎, 杉山 智英, 白井 崇生, 中嶌 賢尚, 奥田 健太郎, 大西 司, 大森 亨, 廣瀬 敬, 足立 満
Organizer
日本呼吸器学会学術講演会
Place of Presentation
神戸
Related Report
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