| Project/Area Number |
21790789
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
ARAYA Jun Jikei University School of Medicine, 医学部, 講師 (90468679)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MORIKAWA Toshiaki 東京慈恵会医科大学, 医学部, 教授 (60292025)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
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| Keywords | 慢性閉塞性肺疾患 / オートファジー / TGF-β / 細胞老化 |
|---|
| Research Abstract |
We demonstrated that autophagy is involved in the suppression of cigarette smoke extract(CSE)-induced cellular senescence in human bronchial epithelial cells. Furthermore, p62-mediated selective autophagic degradation of ubiquitinated proteins is implicated in the regulation of cellular senescence in association with COPD pathogenesis.
|
