Identification of new bronchoconstrictive activity produced by T cells in non-atopic asthmatics

• Project/Area Number: 21790792
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: 独立行政法人国立病院機構相模原病院臨床研究センター (2010); Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital (2009)
• Principal Investigator: KITAMURA Noriko 独立行政法人国立病院機構相模原病院臨床研究センター, 先端技術開発研究部, 研究員 (80415603)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 非アトピー型喘息 / 遅発型喘息反応 / T細胞 / 気管支平滑筋細胞収縮 / コラーゲンゲル / 非アトビー型喘息 / Th2サイトカイン

Research Abstract

We detected a bronchoconstrictive activity produced by T cells in non-atopic asthmatics. The gels embedded normal human bronchial smooth muscle cells contracted gradually and continuously by the culture supernatant of T cells, like the contraction induced by leukotrienes which play critical role in the late asthmatic reaction. It was suggested that this bronchoconstrictive activity is novel one, because the molecular weight and the response of antagonist/immunosuppressant were different from well-known bronchoconstrictors.

Research Products

• [Journal Article] Evaluation of cysteinyl leukotriene-induced contraction of human cultured bronchial smooth muscle cells. (2009)
  • Author(s): Kitamura N., Kaminuma O., Ohtomo T., Kiyokawa N., Kobayashi N., Suko M., Mori A.
  • Journal Title: International Archives of Allergy and Immunology 149 Pages: 83-86
• [Journal Article] Evaluation of cysteinyl leukotriene-induced contraction of human cultured bronchial smooth muscle cells (2009)
  • Author(s): Kitamura N.
  • Journal Title: International Archives of Allergy and Immunology 149 Pages: 83-56
  • Peer Reviewed
• [Presentation] (2010)
  • Author(s): 森晶夫、北村紀子, 他
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-27
• [Presentation] わが国の重症喘息の病態と真菌抗原による非IgE依存性喘息反応 (2010)
  • Author(s): 森晶夫、北村紀子, 他
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-11-27
• [Presentation] (2010)
  • Author(s): Mori A., Kitamura N., et al.
  • Organizer: The 8^<th> Asia Pacific Congress of Allergy, Asthma, and Clinical Immunology 2010
  • Place of Presentation: Shingapore
  • Year and Date: 2010-11-07
• [Presentation] IgE-independent, T cell-dependent bronchoconstriction in vivo and in vitro (2010)
  • Author(s): Mori A., Kitamura N., et al.
  • Organizer: The 8^<th> Asia pacific Congress of Allergy, Asthma, and Clinical Immunology 2010
  • Place of Presentation: Shingapore
  • Year and Date: 2010-11-07
• [Presentation] (2010)
  • Author(s): Mori A., Kitamura N., et al.
  • Organizer: 29^<th> Congress of the European Academy of Allergy and Clinical Immunology 2010
  • Place of Presentation: U.K.
  • Year and Date: 2010-06-08
• [Presentation] T cell dependent bronchoconstriction in vivo and in vitro (2010)
  • Author(s): Mori A., Kitamura N., et al.
  • Organizer: 29^<th> Congress of the European Academy of Allergy and Clinical Immunology 2010
  • Place of Presentation: London, U.K.
  • Year and Date: 2010-06-08
• [Presentation] (2010)
  • Author(s): Mori A., Kitamura N., et al.
  • Organizer: 28^<th> Symposium of the Collegium Internationale Allergologicum 2010
  • Place of Presentation: Italy
  • Year and Date: 2010-04-25
• [Presentation] Analysis of T cell-dependent bronchoconstriction using human cultured bronchial smooth muscle cells (2010)
  • Author(s): Mori A., Kitamura N., et al.
  • Organizer: 28^<th> Symposium of the Collegium Internationale Allergologicum 2010
  • Place of Presentation: Ischia, Italy
  • Year and Date: 2010-04-25
• [Presentation] (2009)
  • Author(s): Mori A., Kitamura N., et al.
  • Organizer: XXI World Allergy Congress
  • Place of Presentation: Argentine
  • Year and Date: 2009-12-09
• [Presentation] Detection of T cell-dependent bronchoconstriction using human cultured bronchial smooth muscle cells (2009)
  • Author(s): Mori A., Kitamura N., et al.
  • Organizer: XXI World Allergy Congress
  • Place of Presentation: Buenos Aires, Argentine
  • Year and Date: 2009-12-09
• [Presentation] (2009)
  • Author(s): 森晶夫、北村紀子, 他
  • Organizer: 第21回日本アレルギー学会春季臨床大会
  • Place of Presentation: 岐阜
  • Year and Date: 2009-06-05
• [Presentation] 重症喘息の機序とその対策 (2009)
  • Author(s): 森晶夫、北村紀子, 他
  • Organizer: 第21回日本アレルギー学会春季臨床大会
  • Place of Presentation: 長良川国際会議場岐阜都ホテル
  • Year and Date: 2009-06-05
• [Presentation] (2009)
  • Author(s): Mori A., Kitamura N., et al.
  • Organizer: The 17^<th> Congress of The International Society for Human and Animal Mycology
  • Place of Presentation: Tokyo (JAPAN)
  • Year and Date: 2009-05-26
• [Presentation] T cell response to Candida albicans acid protease is associated with the isolated late asthmatic response (2009)
  • Author(s): Mori A., Kitamura N., et al.
  • Organizer: The 17^<th> Congress of The International Society for Human and Animal Mycology
  • Place of Presentation: 京王ブラザホテル東京
  • Year and Date: 2009-05-26