| Project/Area Number |
21790792
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | 独立行政法人国立病院機構相模原病院臨床研究センター (2010)
Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital (2009) |
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Principal Investigator |
KITAMURA Noriko 独立行政法人国立病院機構相模原病院臨床研究センター, 先端技術開発研究部, 研究員 (80415603)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 非アトピー型喘息 / 遅発型喘息反応 / T細胞 / 気管支平滑筋細胞収縮 / コラーゲンゲル / 非アトビー型喘息 / Th2サイトカイン |
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| Research Abstract |
We detected a bronchoconstrictive activity produced by T cells in non-atopic asthmatics. The gels embedded normal human bronchial smooth muscle cells contracted gradually and continuously by the culture supernatant of T cells, like the contraction induced by leukotrienes which play critical role in the late asthmatic reaction. It was suggested that this bronchoconstrictive activity is novel one, because the molecular weight and the response of antagonist/immunosuppressant were different from well-known bronchoconstrictors.
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