| Project/Area Number |
21790795
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
DOI Kent 東京大学, 医学部附属病院, 助教 (80505892)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NOIRI Eisei 東京大学, 医学部附属病院, 准教授 (00301820)
YAHAGI Naoki 東京大学, 医学部附属病院, 教授 (60158045)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 腎臓学 / 敗血症性急性腎不全 / 急性腎不全 / 敗血症 / バイオマーカー / 急性腎障害 / L-FABP / 盲腸結紮穿刺腹膜炎モデル |
|---|
| Research Abstract |
Multiple organ failure, especially acute renal failure, complicated with sepsis shows high mortality rate. This study evaluated the utility of urinary L-type fatty acid-binding protein (L-FABP) for early diagnosis of septic acute renal failure using mouse sepsis models. Results of this study demonstrated urinary L-FABP could detect septic acute renal failure earlier than serum creatinine and urinary NAG with higher accuracy.
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