L-type fatty acid-binding protein in septic acute kidney injury
Project/Area Number |
21790795
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Kidney internal medicine
|
Research Institution | The University of Tokyo |
Principal Investigator |
DOI Kent 東京大学, 医学部附属病院, 助教 (80505892)
|
Co-Investigator(Renkei-kenkyūsha) |
NOIRI Eisei 東京大学, 医学部附属病院, 准教授 (00301820)
YAHAGI Naoki 東京大学, 医学部附属病院, 教授 (60158045)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 腎臓学 / 敗血症性急性腎不全 / 急性腎不全 / 敗血症 / バイオマーカー / 急性腎障害 / L-FABP / 盲腸結紮穿刺腹膜炎モデル |
Research Abstract |
Multiple organ failure, especially acute renal failure, complicated with sepsis shows high mortality rate. This study evaluated the utility of urinary L-type fatty acid-binding protein (L-FABP) for early diagnosis of septic acute renal failure using mouse sepsis models. Results of this study demonstrated urinary L-FABP could detect septic acute renal failure earlier than serum creatinine and urinary NAG with higher accuracy.
|
Report
(3 results)
Research Products
(13 results)
-
-
-
-
[Journal Article] Urinary L-type fatty acid-binding protein as a new biomarker of sepsis complicated with acute kidney injury2010
Author(s)
Doi K, Noiri E, Maeda-Mamiya R, Ishii T, Negishi K, Hamasaki Y, Fujita T, Yahagi N, Koide H, Sugaya T, Nakamura T.
-
Journal Title
Crit Care Med.
Volume: 38
Pages: 2037-42
Related Report
Peer Reviewed
-
-
[Journal Article] Urinary L-type fatty acid-binding protein as a new biomarker of sepsis complicated with acute kidney injury.2010
Author(s)
Doi K, Noiri E, Maeda-Mamiya R, Ishii T, Negishi K, Hamasaki Y, Fujita T, Yahagi N, Koide H, Sugaya T, Nakamura T.
-
Journal Title
Critical Care Medicine
Volume: 38
Pages: 2037-2042
Related Report
Peer Reviewed
-
-
[Journal Article] Mild elevation of urinary biomarkers in pre-renal acute kidney injury
Author(s)
Doi K, Katagiri D, Negishi K, Hasegawa S, Hamasaki Y, Fujita T, Matsubara T, Ishii T, Yahagi N, Sugaya T, Noiri E
-
Journal Title
Kidney Int
Volume: (in press)
Related Report
Peer Reviewed
-
-
-
-
-