Sympathoexcitation by brain oxidative stress in hypertension associated with metabolic syndrome and chronic kidney disease

• Project/Area Number: 21790797
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: FUJITA Megumi 東京大学, 医学部附属病院, 特任助教 (50447405)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 高血圧学 / 循環器・高血圧 / 生理学 / 内科 / 脳・神経 / 酸化ストレス / 交感神経 / メタボリックシンドローム / 慢性腎臓病

Research Abstract

We have demonstrated that sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in chronic kidney disease(CKD) model, high salt-loaded uninephrectomized Sprague-Dawley rats. In CKD rats, responses of renal sympathetic nerve to acute intracerebroventricular(ICV) tempol and hypothalamic oxidative stress level were significantly increased. Moreover, chronic ICV tempol showed sympathoinhibitory and depressor effect, along with improvement of renal function.

Research Products

• [Journal Article] Sympathoexcitation by Brain Oxidative Stress Mediates Arterial Pressure Elevation in Salt-induced Chronic Kidney Disease (2012)
  • Author(s): Fujita M, et al
  • Journal Title: Hypertension Volume: 59 Issue: 1 Pages: 105-112
  • DOI: 10.1161/hypertensionaha.111.182923
  • Peer Reviewed
• [Journal Article] Reactive Oxygen Species and the Central Nervous System in Salt-sensitive Hypertension : Possible Relationship to Obesity-induced Hypertension (2012)
  • Author(s): Ando K and Fujita M
  • Journal Title: Clin Exp Pharmacol Physiol Volume: 39 Issue: 1 Pages: 111-116
  • DOI: 10.1111/j.1440-1681.2011.05510.x
  • Peer Reviewed
• [Journal Article] Mineralocorticoid receptor activation : a major contributor to salt-induced renal injury and hypertension in young rats (2011)
  • Author(s): Kawarazaki H, Ando K, Fujita M, Matsui H, Nagae A, Muraoka K, Kawarasaki C, Fujita T.
  • Journal Title: Am J Physiol Renal Physiol Volume: 300(6) Issue: 6 Pages: 1402-1409
  • DOI: 10.1152/ajprenal.00691.2010
  • Peer Reviewed
• [Journal Article] Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (2011)
  • Author(s): Ishikawa A, Kawarazaki H, Ando K, Fujita M, et al
  • Journal Title: Clin Exp Nephrol Volume: 15 Issue: 1 Pages: 30-33
  • DOI: 10.1007/s10157-010-0350-8
  • NAID: 10029004333
  • Peer Reviewed
• [Journal Article] Reactive Oxygen Species and the Central Nervous System in Salt-sensitive Hypertension : Possible Relationship to Obesity-induced Hypertension. (2011)
  • Author(s): 安東克之
  • Journal Title: Clinical & Experimental Pharmacology and Physiology Volume: (印刷中(掲載確定))
  • Peer Reviewed
• [Journal Article] Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10. (2011)
  • Author(s): 石川晃
  • Journal Title: Clinical & Experimental Nephrology Volume: 15 Pages: 30-33
  • Peer Reviewed
• [Journal Article] Mineralocorticoid receptor activation contributes to salt-induced hypertension and renal injury in prepubertal Dahl salt-sensitive rats (2010)
  • Author(s): Kawarazaki H, Ando K, Nagae A, Fujita M, Matsui H, Fujita T.
  • Journal Title: Nephrol Dial Transplant Volume: 25(9) Issue: 9 Pages: 2879-89
  • DOI: 10.1093/ndt/gfq197
  • Peer Reviewed
• [Journal Article] Protective effect of dietary potassium against cardiovascular damage in salt-sensitive hypertension : possible role of its antioxidant action (2010)
  • Author(s): Ando K, Matsui H, Fujita M, et al
  • Journal Title: Curr Vasc Pharmacol Volume: 8 Pages: 59-63
  • Peer Reviewed
• [Journal Article] 中枢性昇圧機序-脳内酸化ストレスを介した交感神経活動亢進- (2010)
  • Author(s): 藤田恵
  • Journal Title: 自律神経 Volume: 47 Pages: 312-317
  • NAID: 10026905948
• [Journal Article] Mineralocorticoid receptor activation contributes to salt-induced hypertension and renal injury in prepubertal Dahl salt-sensitive rats. (2010)
  • Author(s): 河原崎宏雄
  • Journal Title: Nephrology Dialysis Transplantation Volume: 25 Pages: 2879-2889
  • Peer Reviewed
• [Journal Article] Protective effect of dietary potassium against cardiovascular damage in salt-sensitive hypertension : possible role of its antioxidant action (2010)
  • Author(s): 安東克之
  • Journal Title: Current Vascular Pharmacology 8 Pages: 59-63
  • Peer Reviewed
• [Journal Article] Effect of high fat loading in Dahl salt-sensitive rats (2009)
  • Author(s): Nagae A, Fujita M, et al
  • Journal Title: Clin Exp Hypertens Volume: 31 Issue: 5 Pages: 451-461
  • DOI: 10.1080/10641960902825487
  • Peer Reviewed
• [Journal Article] Effect of high fat loading in Dahl salt-sensitive rats (2009)
  • Author(s): 永江愛
  • Journal Title: Clinical & Experimental Hypertension 31 Pages: 451-461
  • Peer Reviewed
• [Presentation] 脳内アルドステロンが酸化ストレスを介した中枢性交感神経活動亢進をもたらし食塩感受性高血圧に関与している (2011)
  • Author(s): 藤田恵
  • Organizer: 第15回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 千里ライフサイエンスセンター
  • Year and Date: 2011-11-26
• [Presentation] 食塩感受性高血圧では脳内においてアルドステロンが酸化ストレスを介し中枢性交感神経活動亢進に寄与している (2011)
  • Author(s): 藤田恵
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 宇都宮東武ホテルグランデ
  • Year and Date: 2011-10-20
• [Presentation] 脳内酸化ストレス・アルドステロンを介した中枢性交感神経活動亢進が慢性腎臓病に関与している (2011)
  • Author(s): 藤田恵
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-06-17
• [Presentation] 脳内酸化ストレス・アルドステロンを介した中枢性交感神経活動亢進が慢性腎臓病に関与している (2011)
  • Author(s): 藤田恵
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2011-04-21
• [Presentation] 脳内抗酸化作用による中枢性交感神経抑制効果が慢性腎臓病を改善する (2010)
  • Author(s): 藤田恵
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2010-10-16
• [Presentation] 脳内抗酸化作用による中枢性交感神経抑制効果が慢性腎臓病を改善する (2010)
  • Author(s): 藤田恵
  • Organizer: 第33会日本高血圧学会総会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2010-10-16
• [Presentation] ympathoexcitation by Oxidative Stress in the Brain Mediates Arterial Pressure Elevation in Metabolic Syndrome (2010)
  • Author(s): 藤田恵
  • Organizer: THE 23^<rd> Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Vancouver convention center(Vancouver, Canada)
  • Year and Date: 2010-09-28
• [Presentation] Sympathoexcitation by Oxidative Stress in the Brain Mediates Arterial Pressure Elevation in Metabolic Syndrome. (2010)
  • Author(s): 藤田恵
  • Organizer: THE 23^<rd> Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Vancouver convention center (Vancouver, Canada)
  • Year and Date: 2010-09-28
• [Presentation] Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in metabolic syndrome (2010)
  • Author(s): 藤田恵
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 2010-03-28
• [Presentation] Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in metabolic syndrome (2010)
  • Author(s): 藤田恵
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: Kyoto International Congress Center(Kyoto)
  • Year and Date: 2010-03-28
• [Presentation] 中枢性昇圧機序-脳内酸化ストレスを介した交感神経活動亢進- (2009)
  • Author(s): 藤田恵
  • Organizer: 第62回日本自律神経学会総会
  • Place of Presentation: ダイワロイネットホテル和歌山(和歌山)
  • Year and Date: 2009-11-05
• [Presentation] 肥満高血圧における脳内酸化ストレス・交感神経活動亢進はインスリン抵抗性改善により抑制される (2009)
  • Author(s): 藤田恵
  • Organizer: 第13回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 大宮ソニックシティ(さいたま市)
  • Year and Date: 2009-10-23
• [Presentation] 肥満高血圧における脳内酸化ストレス・交感神経活動亢進はインスリン抵抗性改善により抑制される (2009)
  • Author(s): 藤田恵
  • Organizer: 第30回日本肥満学会
  • Place of Presentation: アクトシティ浜松(浜松)
  • Year and Date: 2009-10-10
• [Presentation] メタボリックシンドロームの病態に脳内酸化ストレスを介した中枢性交感神経活動亢進が関与している (2009)
  • Author(s): 藤田恵
  • Organizer: 第32回日本高血圧学会総会
  • Place of Presentation: 大津プリンスホテル(大津)
  • Year and Date: 2009-10-03
• [Presentation] Mineralodorticoid Receptor Activation as the key Factor for Salt-sensitivity in Young Rats (2009)
  • Author(s): 河原崎宏雄
  • Organizer: 63rd High Blood Pressure Research Conference
  • Place of Presentation: InterContinental Chicago O' Hare Hotel, USA(Chicago)
  • Year and Date: 2009-09-23
• [Presentation] 脳内酸化ストレスを介した中枢交感神経活動亢進が慢性腎臓病の病態に関与している (2009)
  • Author(s): 藤田恵
  • Organizer: 第52回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-06-03
• [Presentation] 肥満高血圧における脳内酸化ストレス・交感神経系活動亢進はインスリン抵抗性改善により抑制される (2009)
  • Author(s): 藤田恵
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 群馬県民会館、商工会議所(前橋)
  • Year and Date: 2009-04-25
• [Presentation] 肥満高血圧における脳内酸化ストレス・交感神経系活動亢進はインスリン抵抗性改善により抑制される (2009)
  • Author(s): 藤田恵
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 群馬県民会館、商工会議所
  • Year and Date: 2009-04-25