Sympathoexcitation by brain oxidative stress in hypertension associated with metabolic syndrome and chronic kidney disease
Project/Area Number |
21790797
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Kidney internal medicine
|
Research Institution | The University of Tokyo |
Principal Investigator |
FUJITA Megumi 東京大学, 医学部附属病院, 特任助教 (50447405)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 高血圧学 / 循環器・高血圧 / 生理学 / 内科 / 脳・神経 / 酸化ストレス / 交感神経 / メタボリックシンドローム / 慢性腎臓病 |
Research Abstract |
We have demonstrated that sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in chronic kidney disease(CKD) model, high salt-loaded uninephrectomized Sprague-Dawley rats. In CKD rats, responses of renal sympathetic nerve to acute intracerebroventricular(ICV) tempol and hypothalamic oxidative stress level were significantly increased. Moreover, chronic ICV tempol showed sympathoinhibitory and depressor effect, along with improvement of renal function.
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Report
(4 results)
Research Products
(31 results)