Mechanism of IgA deposition in mesangial cells in IgA nephropathy and application for therapy

• Project/Area Number: 21790800
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Niigata University
• Principal Investigator: KANEKO Yoshikatsu 新潟大学, 医歯学総合病院, 助教 (80444157)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 腎臓学 / IgA腎症 / メサンギウム細胞 / 糖鎖不全 / インテグリン

Research Abstract

Immunoglobulin A nephropathy(IgAN) is the most common form of primary glomerulonephritis and is characterized by glomerular mesangial IgA1 deposition, however, precise mechanism of IgA1 deposition are still unclear. The aim of the present study is to identify the receptor for IgA1 in mesangial cells using IgA1 probe, and integrinα1/β1 andα2/β1 heterodimer was identified as the receptors for IgA1.

Research Products

• [Journal Article] Integrinα1/β1 andα2/β1 as a receptor for IgA1 in human glomerular mesangial cells in IgA nephropathy (2012)
  • Author(s): Yoshikatsu Kaneko, Tadashi Otsuka, Yohei Tsuchida, Fumitake Gejyo, Ichiei Narita
  • Journal Title: Int Immunol Volume: 24 Pages: 219-232
  • Peer Reviewed
• [Journal Article] Integrin alpha1/beta1 and alpha2/beta1 as a receptor for IgA1 in human glomerular mesangial cells in IgA nephropathy (2012)
  • Author(s): Kaneko Y, et al.
  • Journal Title: Int Immunol Volume: (印刷中) Issue: 4 Pages: 219-232
  • DOI: 10.1093/intimm/dxr125
  • Peer Reviewed
• [Presentation] Integrin α2/β1 as a novel galactose-deficient IgA1 receptor on human mesangial cells (2011)
  • Author(s): Yoshikatsu Kaneko, et al
  • Organizer: 2011 World Congress of Nephrology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2011-04-09
• [Presentation] メサンギウム細胞上の糖鎖不全IgA1受容体候補としてのintegrinα2/β1 (2011)
  • Author(s): 金子佳賢,土田陽平,下条文武,成田一衛
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Integrinα2/β1 as a novel galactose-deficient IgA1 receptor on human mesangial cells (2011)
  • Author(s): Yoshikatsu Kaneko, Takeshi Takeda, Yohei Tsuchida, Ichiei Narita
  • Organizer: 2011 World Congress of Nephrology
  • Place of Presentation: Vancouver, Canada
• [Presentation] 糖鎖不全IgAに対するメサンギウム細胞上受容体の探索 (2010)
  • Author(s): 金子佳賢
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-06-16
• [Presentation] Receptor for IgAl with galactose-deficient O-linked glycans on human mesangium cells (2010)
  • Author(s): Yoshikatsu Kaneko
  • Organizer: International Society of Nephrology-Nexus Kyoto
  • Place of Presentation: 京都市
  • Year and Date: 2010-04-16
• [Presentation] 糖鎖不全IgAに対するメサンギウム細胞上受容体の探索 (2010)
  • Author(s): 金子佳賢,土田陽平,成田一衛
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸
• [Presentation] Receptor for IgA1 with galactose-deficient O-linked glycans on human mesangium cells (2010)
  • Author(s): Yoshikatsu Kaneko, Yohei Tsuchida, Ichiei Narita
  • Organizer: ISN Nexus Simposia
  • Place of Presentation: Kyoto, Japan
• [Presentation] 糖鎖不全IgAに対するメサンギウム細胞上受容体の同定 (2009)
  • Author(s): 金子佳賢
  • Organizer: 第52回日本腎臓学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-06-04
• [Presentation] 糖鎖不全IgAに対するメサンギウム細胞上受容体の同定 (2009)
  • Author(s): 金子佳賢,成田一衛,下条文武
  • Organizer: 第52回日本腎臓学会学術総会
  • Place of Presentation: 横浜