human ES・iPS-derived endothelial cells for chronic kidney disease

Research Project

Project/Area Number	21790805
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Kidney internal medicine
Research Institution	Keio University
Principal Investigator	HOMMA Koichiro Keio University, 医学部, 助教 (10383762)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	ヒトES細胞 / ヒトiPS細胞 / 血管内皮細胞 / 慢性腎臓病 / 低酸素 / microRNA / ヒトES・iPS細胞 / 抗加齢因子
Research Abstract	We compared the functionality of human adult ECs (HAECs), human ES-derived ECs (ESECs) and human iPS-derived ECs (iPSECs). ESECs were significantly superior to HAECs in cell functions. Sirt1 plays a key role in the high cellular function of ESECs and iPSECs. Although further in vivo investigations are required, this study initially demonstrated the potential of ESECs and iPSECs as the cell source for regenerative medicine.