| Project/Area Number |
21790809
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAMOTO Ryohei Osaka University, 医学部附属病院, 医員 (00533853)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 慢性糸球体腎炎 / IgA腎症 / 遺伝子多型 / single nucleotide polymorphism (SNP) / SNP / GPIa / ICAM-1 / 動脈硬化 / Single Nucleotide Polymorphism(SNP) / GPIa C807T / GPIa G873A / ICAM-1 A1548G / PREDICT-IgAN |
|---|
| Research Abstract |
The aim of the present multicenter longitudinal cohort was identification of gene polymorphisms contributing to progression of chronic glomerulonephritis among 100 kinds of atherosclerotic diseases-related gene polymorphisms, mainly single Nucleotide Polymorphisms (SNPs). We determined 100 gene polymorphisms of 320 patients with IgA nephropathy, a most common chronic glomerulonephritis, and identified glycoprotein Ia (GPIa) C807T/G873A and intracellular adhesion molecule-1 (ICAM-1) A1548G(K469E) as significant predictors of progression of IgA nephropathy. Based on the clinical database of approximately 1000 patients with IgA nephropathy, we also revealed the number of cigarettes was a significant predictor of progression of IgA nephropathy. The results of the present study strongly suggested that atherosclerotic disease-related factors play pivotal roles in progression of IgA nephropathy, providing a deep insight into the treatment strategy of IgA nephropathy.
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