Gene polymorphisms contributing to progression of chronic glomerulonephritis

• Project/Area Number: 21790809
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Osaka University
• Principal Investigator: YAMAMOTO Ryohei Osaka University, 医学部附属病院, 医員 (00533853)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 慢性糸球体腎炎 / IgA腎症 / 遺伝子多型 / single nucleotide polymorphism (SNP) / SNP / GPIa / ICAM-1 / 動脈硬化 / Single Nucleotide Polymorphism(SNP) / GPIa C807T / GPIa G873A / ICAM-1 A1548G / PREDICT-IgAN

Research Abstract

The aim of the present multicenter longitudinal cohort was identification of gene polymorphisms contributing to progression of chronic glomerulonephritis among 100 kinds of atherosclerotic diseases-related gene polymorphisms, mainly single Nucleotide Polymorphisms (SNPs). We determined 100 gene polymorphisms of 320 patients with IgA nephropathy, a most common chronic glomerulonephritis, and identified glycoprotein Ia (GPIa) C807T/G873A and intracellular adhesion molecule-1 (ICAM-1) A1548G(K469E) as significant predictors of progression of IgA nephropathy. Based on the clinical database of approximately 1000 patients with IgA nephropathy, we also revealed the number of cigarettes was a significant predictor of progression of IgA nephropathy. The results of the present study strongly suggested that atherosclerotic disease-related factors play pivotal roles in progression of IgA nephropathy, providing a deep insight into the treatment strategy of IgA nephropathy.

Research Products

• [Journal Article] Cigarette smoking and progression of IgA nephropathy. (2010)
  • Author(s): Yamamoto R, Nagasawa Y, Shoji T, Iwatani H, Hamano T, Kawada N, Inoue K, Uehata T, Kaneko T, Okada N, Moriyama T, Horio M, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y
  • Journal Title: Am J Kidney Dis 56 Pages: 313-324
  • Peer Reviewed
• [Journal Article] Pathology: Oxford IgA nephropathy classification : Valid for children? (2010)
  • Author(s): Yamamoto R, Nagasawa Y
  • Journal Title: Nat Rev Nephrol 6 Pages: 638-639
  • Peer Reviewed
• [Journal Article] Urinary type iv collagen in nondiabetic kidney disease. (2010)
  • Author(s): Furumatsu Y, Nagasawa Y, Shoji T, Yamamoto R, Iio K, Matsui I, Takabatake Y, Kaimori JY, Iwatani H, Kaneko T, Tsubakihara Y, Imai E, Isaka Y, Rakugi H
  • Journal Title: Nephron Clin Pract 117
  • Peer Reviewed
• [Journal Article] Incidence of symptomatic stroke and cancer in chronic kidney disease patients treated with epoetins. (2010)
  • Author(s): Imai E, Yamamoto R, Suzuki H, Watanabe T
  • Journal Title: Clin Exp Nephrol 14 Pages: 445-452
  • NAID: 10027707191
  • Peer Reviewed
• [Journal Article] Impact of age and overt proteinuria on outcomes of stage 3 to 5 chronic kidney disease in a referred cohort. (2010)
  • Author(s): Obi Y, Kimura T, Nagasawa Y, Yamamoto R, Yasuda K, Sasaki K, Kitamura H, Imai E, Rakugi H, Isaka Y, Hayashi T
  • Journal Title: Clin J Am Soc Nephrol 5 Pages: 1558-1565
  • Peer Reviewed
• [Journal Article] Microarray analysis of tonsils in immunoglobulin a nephropathy patients. (2010)
  • Author(s): Iio K, Nagasawa Y, Iwatani H, Yamamoto R, Horii A, Okuzaki D, Furumatsu Y, Inohara H, Nojima H, Imai E, Isaka Y, Rakugi H
  • Journal Title: Biochem Biophys Res Commun 393 Pages: 565-570
  • Peer Reviewed
• [Journal Article] Specialist care and improved long-term survival of dialysis patients. (2010)
  • Author(s): Furumatsu Y, Nagasawa Y, Yamamoto R, Iio K, Iwatani H, Matsui I, Takabatake Y, Kawada N, Shoji T, Imai E, Isaka Y, Rakugi H
  • Journal Title: Nephrol Dial Transplant 25 Pages: 1930-1935
  • Peer Reviewed
• [Journal Article] Therapeutic apheresis in liver transplantation. (2010)
  • Author(s): Nagasawa Y, Yamamoto R, Marubashi S
  • Journal Title: Transplantationsmedizin 22
• [Journal Article] ネフローゼ症候群の疫学 (2010)
  • Author(s): 山本陵平
  • Journal Title: 医学のあゆみ 233 Pages: 1058-1061
• [Journal Article] Cigarette Smoking and Progression of IgA Nephropathy (2010)
  • Author(s): 山本陵平
  • Journal Title: American Journal of Kidney Diseases Volume: 56 Pages: 313-324
  • Peer Reviewed
• [Journal Article] A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of polymorphism research to distinguish genetic factors contributing to progression of iga nephropathy (PREDICT-IgAN). (2009)
  • Author(s): Yamamoto R, Nagasawa Y, Shoji T, Inoue K, Uehata T, Kaneko T, Okada T, Yamauchi A, Tsubakihara Y, Imai E, Isaka Y, Rakugi H
  • Journal Title: Nephrol Dial Transplant 24 Pages: 3686-3694
  • Peer Reviewed
• [Journal Article] A novel classification for IgA nephropathy. (2009)
  • Author(s): Yamamoto R, Imai E
  • Journal Title: Kidney Int 76 Pages: 477-480
  • Peer Reviewed
• [Journal Article] IgA腎症の進行と遺伝子多型 (2009)
  • Author(s): 山本陵平
  • Journal Title: 医学のあゆみ 231 Pages: 847-848
• [Journal Article] 喫煙と慢性腎臓病. (2009)
  • Author(s): 山本陵平, 長澤康行
  • Journal Title: CLINICIAN 56 Pages: 639-644
• [Journal Article] A candidate gene approach to genetic prognostic factors of IgA nephropathy-a result of Polymorphism Research to Distinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN) (2009)
  • Author(s): Yamamoto R, Nagasawa Y, Shoji T, Inoue K, Uehata T, Kaneko T, Okada T, Yamauchi A, Tsubakihara Y, Imai E, Isaka Y, Rakugi H
  • Journal Title: Nephrol Dial Transplant 24 Pages: 3686-3694
  • Peer Reviewed
• [Journal Article] A novel classification for IgA nephropathy (2009)
  • Author(s): Yamamoto R, Imai E
  • Journal Title: Kidney Int 76 Pages: 477-480
  • Peer Reviewed
• [Journal Article] Early plasma exchange for progressive liver failure in recipients of adult-to-adult living-related liver transplants (2009)
  • Author(s): Yamamoto R, Nagasawa Y, Marubashi S, Furumatsu Y, Iwatani H, Iio K, Matsui I, Dono K, Imai E, Monden M, Isaka Y
  • Journal Title: Blood Purif 28 Pages: 40-46
  • Peer Reviewed
• [Journal Article] IgA腎症の進行と遺伝子多型 (2009)
  • Author(s): 山本陵平
  • Journal Title: 医学のあゆみ 321 Pages: 847-848
• [Journal Article] Cigarette Smoking and Progression of IgA Nephropathy
  • Author(s): Yamamoto R, Nagasawa N, Shoji T, Iwatani H, Hamano T, Kawada N, Inoue K, Uehata T, Kaneko T, Okada N, Moriyama T, Horio M, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka.Y
  • Journal Title: Am J Kidney Dis (in press)
  • Peer Reviewed
• [Journal Article] Specialist care and improved long-term survival of dialysis patients.
  • Author(s): Furumatsu Y, Nagasawa Y, Yamamoto R, Iio K, Iwatani H, Matsui I, Takabatake Y, Kawada N, Shoji T, Imai E, Isaka Y, Rakugi H
  • Journal Title: Nephrol Dial Transplant (in press)
  • Peer Reviewed
• [Journal Article] Microarray analysis of tonsils in immunoglobulin A nephropathy patients
  • Author(s): Iio K, Nagasawa Y, Iwatani H, Yamamoto R, Horii A, Okuzaki D, Furumatsu Y, Inohara H, Nojima H, Imai E, Isaka Y, Rakugi H :
  • Journal Title: Biochem Biophys Res Commun (in press)
  • Peer Reviewed
• [Presentation] Short sleep duration as a predictor of proteinuria in urban employees (2011)
  • Author(s): 山本陵平
  • Organizer: 第5回CKDフォーラム
  • Place of Presentation: キャッスルホテル名古屋
  • Year and Date: 2011-02-12
• [Presentation] Cigarette smoking abrogates a renoprotective effect of renin-angiotensin-aldosterone system (RAAS) blockade in patients with IgA nephropathy (2010)
  • Author(s): 山本陵平
  • Organizer: 米国腎臓学会
  • Place of Presentation: Denvor convention center
  • Year and Date: 2010-11-20
• [Presentation] Cigarette smoking abrogates a renoprotective effect of renin-angiotensin-aldosterone system (RAAS) blockade in patients with IgA nephropathy. (2010)
  • Author(s): 山本陵平
  • Organizer: American Society of Nephrology, 43nd Annual Meeting
  • Place of Presentation: Denvor Convention Center(USA)
  • Year and Date: 2010-11-09
• [Presentation] Cigarette smoking abrogates a renoprotective effect of renin-angiotensin-aldosterone system (RAAS) blockade in patients with IgA nephropathy (2010)
  • Author(s): 山本陵平
  • Organizer: 欧州腎臓学会
  • Place of Presentation: Munich convention center
  • Year and Date: 2010-06-27
• [Presentation] IgA腎症におけるrenin-angiotensin-aldosterone system抑制薬(RAASB)による腎保護作用と喫煙 (2010)
  • Author(s): 山本陵平
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-06-17
• [Presentation] Cigarette smoking abrogates a renoprotective effect of renin-angiotensin-aldosterone system (RAAS) blockade in patients with IgA nephropathy (2010)
  • Author(s): 山本陵平
  • Organizer: 国際腎臓学会Nexus Symposium 2010
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2010-04-17
• [Presentation] IgA腎症におけるRenin-Angiotensin-Aldosterone系抑制薬の腎保護効果の予測因子としての喫煙の重要性 (2010)
  • Author(s): 山本陵平
  • Organizer: 第33回IgA腎症研究会
  • Place of Presentation: 東京ステーションコンファレンス
  • Year and Date: 2010-01-30
• [Presentation] A candidate gene approach to genetic prognostic factors of IgA nephropathy (2009)
  • Author(s): 山本陵平
  • Organizer: 米国腎臓学会
  • Place of Presentation: San Diego convention center
  • Year and Date: 2009-10-30
• [Presentation] A Candidate Gene Approach to Genetic Prognostic Factors of IgA Nephropathy (2009)
  • Author(s): Ryohei Yamamoto, Yasuyuki Nagasawa, Tatsuya Shoji, Kazunori Inoue, Takuya Uehata, Tetsuya Kaneko, Noriyuki Okada, Atsushi Yamauchi, Yoshiharu Tsubakihara, Enyu Imai, Yoshiharu Isaka, Hiromi Rakugi
  • Organizer: American Society of Nephrology 42nd Annual Meeting
  • Place of Presentation: アメリカ サンディエゴ
  • Year and Date: 2009-10-29
• [Presentation] ICAM-1 A1548GとGPIa C807T/G873AはIgA腎症の腎予後関連因子である (2009)
  • Author(s): 山本陵平
  • Organizer: 第52回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-06-05
• [Remarks] ホームページ等
  • URL: http://www.med.osaka-u.ac.jp/pub/kid/clinicalresearch.html
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/kid/clinicalresearch.html
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/kid/clinicalresearch.html