The role of nuclear hormone receptor LXR on the pathogenesis of diabetic nephropathy

• Project/Area Number: 21790813
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: Okayama University
• Principal Investigator: OGAWA Daisuke Okayama University, 大学院・医歯薬学総合研究科, 准教授 (70535195)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 糖尿病性腎症 / 核内受容体 / LXR / 糖尿病

Research Abstract

Several studies have reported that activation of LXR is atheroprotective; however, the role of LXR in renal function remains unclear. Here, we report the renoprotective effects of LXR activation in a model of streptozotocin-induced diabetic nephropathy. These findings uncover a previously unrecognized mechanism for the renoprotective effects of LXR agonists and support the concept that LXR agonists may offer a novel therapeutic approach for the treatment of diabetic nephropathy.

Research Products

• [Journal Article] P-selectin glycoprotein ligand-1 deficiency is protective against obesity-related insulin resistance. (2011)
  • Author(s): Sato C, Shikata K, Hirota D, Sasaki M, Nishishita S, Miyamoto S, Kodera R, Ogawa D, Kajitani N, Makino H.
  • Journal Title: Diabetes 60 Pages: 189-99
  • Peer Reviewed
• [Journal Article] Glucagon-like peptide-1 receptor agonist ameliorates diabetic renal injuries through anti-inflammatory effects. (2011)
  • Author(s): Kodera R, Shikata K, Usui HK, Takatsuka T, Miyamoto S, Sasaki M, Kajitani N, Nishishita S, Sarai K, Hirota D, Sato C, Ogawa D, Makino H.
  • Journal Title: Diabetologia 54 Pages: 965-78
  • Peer Reviewed
• [Journal Article] Activation of peroxisome proliferator-activated receptor δ inhibits streptozotocin-induced diabetic nephropathy through anti-inflammatory mechanisms in mice. (2011)
  • Author(s): Matsushita Y, Ogawa D, Wada J, Noriko Y, Shikata K, Sato C, Tachibana H, Toyota N, Makino H.
  • Journal Title: Diabetes 60 Pages: 960-8
  • Peer Reviewed
• [Journal Article] Emphysematous cystitis in a patient with type 2 diabetes mellitus. (2011)
  • Author(s): Toyota N, Ogawa D, Ishii K, Hirata K, Wada J, Shikata K, Makino H.
  • Journal Title: Acta Med Okayama 65 Pages: 129-33
  • NAID: 120002970772
  • Peer Reviewed
• [Journal Article] Intercellular adhesion molecule-1 plays a critical role for glomeruloscrelosis after subtotal nephrectomy. (2011)
  • Author(s): Kido Y*, Ogawa D*, Shikata K, Sasaki M, Nagase R, Okada S, Usui-Kataoka H, Wada J, Makino H.
  • Journal Title: Clin Exp Nephrol 15 Pages: 212-9
  • Peer Reviewed
• [Journal Article] The macrophage is a key factor in renal injuries caused by glomerular hyperfiltration. (2011)
  • Author(s): Sasaki M, Shikata K, Okada S, Miyamoto S, Nishishita S, Usui HK, Sato C, Wada J, Ogawa D, Makino H.
  • Journal Title: Acta Med Okayama 65 Pages: 81-9
  • NAID: 120002970764
  • Peer Reviewed
• [Journal Article] Intercellular adhesion molecule-1 plays a critical role inglomerulosclerosis after subtotal nephrectomy (2011)
  • Author(s): 城戸雄一
  • Journal Title: Clin Exp Nephrol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Diabetic nephropathy remission and regression team trial in Japan (DNETT-Japan) : rationale and study design. (2010)
  • Author(s): Shikata K, Haneda M, Koya D, Suzuki Y, Tomino Y, Yamada K, Maeda S, Kawakami N, Uzu T, Nishimura M, Sato C, Ogawa D, Makino H.
  • Journal Title: Diabetes Res Clin Pract 87 Pages: 228-32
  • Peer Reviewed
• [Journal Article] Optimal cutoff point of waist circumference for the diagnosis of metabolic syndrome in Japanese subjects. (2010)
  • Author(s): Ogawa D, Kahara K, Shigematsu T, Fujii S, Hayakawa N, Okazaki M, Makino H.
  • Journal Title: J Diabetes Invest 1 Pages: 117-20
  • Peer Reviewed
• [Journal Article] Peramivir for severe influenza infection in a patient with diabetic nephropathy. (2010)
  • Author(s): Nasu T, Ogawa D, Wada J, Makino H.
  • Journal Title: Am J Respir Crit Care Med 182 Pages: 1209-10
  • Peer Reviewed
• [Journal Article] Peramivir for severe influenza infection in a patient with diabetic nephropathy (2010)
  • Author(s): 那須達世
  • Journal Title: Am J Respir Crit Care Med Volume: VOL.182 Pages: 1209-10
  • Peer Reviewed
• [Journal Article] Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan) : Rationale and Study design (2010)
  • Author(s): 四方賢一
  • Journal Title: Diabetes Research and Clinical Practice VOL.87 Pages: 228-232
  • Peer Reviewed
• [Journal Article] Optimal Cutoff Point of Waist Circumference for the Diagnosis of Metabolic Syndrome in Japanese Subjects (2010)
  • Author(s): 小川大輔
  • Journal Title: Journal of Diabetes Investigation ((印刷中))
  • Peer Reviewed
• [Presentation] 糖尿病マウスにおけるPPARδアゴニストの腎保護効果 (2010)
  • Author(s): 松下裕一、小川大輔、佐藤千景、和田淳、四方賢一、槇野博史
  • Organizer: 第25回日本糖尿病合併症学会
  • Place of Presentation: 大津
  • Year and Date: 2010-10-23
• [Presentation] 糖尿病性腎症の進展における核内受容体PPARδの役割の検討 (2010)
  • Author(s): 小川大輔、松下裕一、四方賢一、和田淳、佐藤千景、槇野博史
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17
• [Presentation] 糖尿病性腎症におけるPPARδアゴニストの有効性の検討 (2010)
  • Author(s): 松下裕一、小川大輔、佐藤千景、和田淳、四方賢一、槇野博史
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-29
• [Presentation] 糖尿病性腎症の進展におけるPPARδアゴニストの有効性の検討 (2010)
  • Author(s): 小川大輔
  • Organizer: 第24回日本糖尿病・肥満動物学会
  • Place of Presentation: ホテルコスモスクエア国際交流センター(大阪府)
  • Year and Date: 2010-01-22
• [Book] 糖尿病診療ガイド (2011)
  • Author(s): 小川大輔, 槇野博史
  • Publisher: 南山堂
• [Book] CKDと心血管病を理解する (2010)
  • Author(s): 小川大輔, 槇野博史
  • Publisher: 中山書店
• [Book] (2010)
  • Author(s): 小川大輔, 槇野博史
  • Publisher: メディカルレビュー社