Therapeutic approach for kidney diseases by regenerative medicine
| Project/Area Number |
21790816
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
INOUE Kosuke 高知大学, 教育研究部医療学系, 助教 (00403907)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 腎臓 / 再生医学 / 急性腎不全 / 尿細管障害 / 急性腎障害 / dedifferentiation / 再生医療 / 尿細管 / オートファジー / アポトーシス / 血液透析 / 腎保護作用 |
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| Research Abstract |
The patients of ESKD（End Stage of Kidney Disease） increase up-to 300,000 in Japan. However the therapeutic methods are still limited. We tried novel regenerative methodology to develop new therapies to kidney diseases. Our result shows that Delta/Notch/Hes pathway is activated after ischemic acute kidney injury and plays a role in the proliferation of renal tubules. To regulate embryonic genes could provide a renewable source of cells for use in regenerative therapy for renal diseases.
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] Upregulation of HNF1 during experimental acute kidney injury palys a crucial role in renal tuble regeneration2012
Author(s)
Ogata K, Shimamura Y, Hamada K,Hisa M, Bun M,Okada N, Inoue K, Taniguchi Y, Ishinara M, Kagawa T, Horino T, Fujimoto S, Terada Y
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Journal Title
Am J Physiol Reneal Physiol
Related Report
Peer Reviewed
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[Journal Article] Serum levels of soluble secreted α-Klotho are decmaking it a probable novel biomarker for early diagnosisreased in the early stages of chronic kindney disease2012
Author(s)
Shimamura Y, Hamada K, Inoue K, Ogata K, Ishihara M, Kagawa T, Inoue M, Fujimoto S, Ikebe M, Yuasa K, Yamanaka S, Sugiura T, Terada Y
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Journal Title
Clin Exp Nephrol
Volume: 16
Pages: 722-729
Related Report
Peer Reviewed
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[Journal Article] Possible involvement of intracellular angiotensin IIreceptor in high-glucose-induceddamage in renal proximal tubular cells2011
Author(s)
Takao T, Horino T, Kagawa T, Matsumoto R, Shimamura Y,Ogata K, Inoue K, Taniguchi Y, Taguchi T, Morita T, Terada Y
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Journal Title
Journal of Nephrology
Volume: 24(3)
Pages: 218-224
Related Report
Peer Reviewed
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[Journal Article] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo2010
Author(s)
Inoue K, Kuwana H, Shimamura Y, Ogata K, Taniguchi Y, Kagawa T, Horino T, Takao T, Morita T, Sasaki S, Mizushima N, Terada Y
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Journal Title
Clin Exp Nephrol
Volume: 14
Pages: 112-122
NAID
Related Report
Peer Reviewed
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[Presentation] Small Heat Shock Protein beta-1 (HSPB1 or HSP27) Is Up-Regulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in the Acute Kidney Injury In Vitro and In Vivo2012
Author(s)
Inoue K, Ogata K, Ishihara M, Urushido M, Okada N, Shimamura Y, Hamada K, Kagawa T, Takao T, Terada Y
Organizer
KIDNEY WEEK 2012
Place of Presentation
San Diego,USA
Related Report
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[Presentation] Cisplatin-Induced Macroautophagy Occurs Prior to Apoptosis in Proximal Tubules In Vivo2009
Author(s)
Inoue K, Kuwana H, Shimamura Y, Ogata , Taniguchi Y, Kagawa T, Horino T, Takao T, Morita T, Ikeda Y, Sasaki S, and Terada Y
Organizer
The American society of NephrologyRenal week
Place of Presentation
San Diego,USA
Related Report
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