Protective role of PEDF in transgenic diabetic nephropathy mouse.

Research Project

Project/Area Number	21790824
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Kidney internal medicine
Research Institution	Kurume University
Principal Investigator	MATSUI Takanori Kurume University, 医学部, 助教 (10425233)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	糖尿病 / シグナル伝達
Research Abstract	Pigment epithelium derived factor (PEDF) is expected to lead to improved therapies for the treatment of diabetic nephropathy. To clarify whether PEDF improves early-stage diabetic nephropathy by antioxidative stress activities, production of transgenic mouse which express of PEDF is induced by tetracycline was attempted.