Analyses of B cell in multiple sclerosis

• Project/Area Number: 21790828
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Tohoku University
• Principal Investigator: NAKASHIMA Ichiro Tohoku University, 大学院・医学系研究科, 助教 (50333810)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 脳神経疾患 / 多発性硬化症 / B細胞 / 視神経脊髄炎 / 末梢血単核球 / サイトカイン / 自己抗体 / 免疫抑制剤 / 神経免疫 / フローサイトメトリー

Research Abstract

By stimulating with cytokines, peripheral B cells of multiple sclerosis produced oligoclonal IgG bands while B cells of neuromyelitis optica produced anti-aquaporin-4 antibodies. Serum BAFF level was indicated as an important factor for antibody production in these diseases.

Research Products

• [Journal Article] Transient increases in anti-aquaporin-4 antibody titers following rituximab treatment in neuromyelitis optica, in association with elevated serum BAFF levels. (2011)
  • Author(s): Nakashima I, Takahashi T, Cree BA, Kim HJ, Suzuki C, Genain CP, Vincent T, Fujihara K, Itoyama Y, Bar-Or A.
  • Journal Title: J Clin Neurosci (in press)
  • Peer Reviewed
• [Journal Article] Herpes labialis in multiple sclerosis with a trigeminal lesion. (2011)
  • Author(s): Suzuki N., Mizuno H., Nakashima I., Itoyama Y.
  • Journal Title: Intern Med Volume: 50 Pages: 259-259
  • NAID: 130000413104
  • Peer Reviewed
• [Presentation] 末梢血B細胞培養系を用いた免疫抑制剤による自己抗体産生抑制効果の検討 (2011)
  • Author(s): 鈴木千尋、中島一郎, 他
  • Organizer: 第52回日本神経学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-19
• [Presentation] 視神経脊髄炎における経口ステロイド剤の再発予防効果 (2010)
  • Author(s): 高井良樹、中島一郎、高橋利幸、三須建郎、藤原一男、糸山泰人
  • Organizer: 第22回神経免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-16
• [Presentation] NMOのrituximab治療における抗AQP4抗体価の変動とBAFFの関連について (2010)
  • Author(s): 中島一郎、高橋利幸、クリー・ブルース、三須建郎、藤原一男、バーオール・アミット、糸山泰人
  • Organizer: 第22回神経免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-16
• [Presentation] Effective Protocol for NMO-Attack Prevention by Oral Prednisolone (2010)
  • Author(s): Nakashima I., et al.
  • Organizer: 3rd Congres of the Pan-Asian Committee on Treatment and Research of Multiple Sclerosis
  • Place of Presentation: インドネシア・バリ
  • Year and Date: 2010-08-26
• [Presentation] NMOの rituximab治療における抗AQP4抗体価の変動と血清BAFFの関連について (2010)
  • Author(s): 中島一郎, 他
  • Organizer: 第51回日本神経学会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-20
• [Presentation] NMOのrituximab治療における抗AQP4抗体価の変動と血清BAFFの関連について (2010)
  • Author(s): 中島一郎
  • Organizer: 第51回日本神経学会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-20
• [Presentation] Influence of Glial Factors on B Cell Biology : Implication in Multiple Sclerosis Pathogenesis. (2010)
  • Author(s): Lebeurrier N, Nakashima I, et al.
  • Organizer: 62nd annual meeting of American Academy of Neurology
  • Place of Presentation: Toronto
  • Year and Date: 2010-04-13
• [Presentation] NMOのrituximab治療における抗AQP4抗体価の変動とBAFFの関連について (2010)
  • Author(s): 中島一郎, 他
  • Organizer: 第22回日本神経免疫学会
  • Place of Presentation: 東京・日経ホール
  • Year and Date: 2010-03-18
• [Presentation] Anti-aquaporin 4 autoantibodies increase transiently after rituximab treatment in neuromyelitis optica : an association with B-cell activating factor. (2009)
  • Author(s): Nakashima I, Takahashi T, et al.
  • Organizer: 25th Congress of the European Committee for the Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Dusseldorf, Germany
  • Year and Date: 2009-09-10
• [Presentation] 視神経脊髄炎の末梢血B細胞の解析 (2009)
  • Author(s): 鈴木千尋、中島一郎, 他
  • Organizer: 第50回日本神経学会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2009-05-22
• [Presentation] 多発性硬化症中枢神経における抗体産生機序の解明 (2009)
  • Author(s): 中島一郎, 他
  • Organizer: 第50回日本神経学会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2009-05-20
• [Presentation] Anti-Aquaporin-4 Antibody Production from Peripheral B Cells in Neuromyelitis Optica. (2009)
  • Author(s): Suzuki C, Nakashima I, et al.
  • Organizer: 61st annual meeting of American Academy of Neurology
  • Place of Presentation: Seattle
  • Year and Date: 2009-04-30