Analyses of B cell in multiple sclerosis
| Project/Area Number |
21790828
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKASHIMA Ichiro Tohoku University, 大学院・医学系研究科, 助教 (50333810)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 脳神経疾患 / 多発性硬化症 / B細胞 / 視神経脊髄炎 / 末梢血単核球 / サイトカイン / 自己抗体 / 免疫抑制剤 / 神経免疫 / フローサイトメトリー |
|---|
| Research Abstract |
By stimulating with cytokines, peripheral B cells of multiple sclerosis produced oligoclonal IgG bands while B cells of neuromyelitis optica produced anti-aquaporin-4 antibodies. Serum BAFF level was indicated as an important factor for antibody production in these diseases.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Transient increases in anti-aquaporin-4 antibody titers following rituximab treatment in neuromyelitis optica, in association with elevated serum BAFF levels.2011
Author(s)
Nakashima I, Takahashi T, Cree BA, Kim HJ, Suzuki C, Genain CP, Vincent T, Fujihara K, Itoyama Y, Bar-Or A.
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Journal Title
J Clin Neurosci (in press)
Related Report
Peer Reviewed
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