PET imaging of brain oxidative stress in patients with Parkinson's disease

• Project/Area Number: 21790838
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: University of Fukui
• Principal Investigator: IKAWA Masamichi University of Fukui, 医学部附属病院, 助教 (60444212)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 神経機能画像学 / パーキンソン病 / 酸化ストレス / 神経変性疾患 / PET / ミトコンドリア機能障害 / 脳機能画像

Research Abstract

[^<62>Cu]ATSM PET imaging demonstrated that striatal oxidative stress was enhanced in patients with Parkinson's disease compared with the controls and was increased with the progression of disease severity. These findings indicated that oxidative stress associates with striatal neurodegeneration in Parkinson's disease.

Research Products

• [Journal Article] Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET. (2011)
  • Author(s): Ikawa M, Okazawa H, Kudo T, Kuriyama M, Fujibayashi Y, Yoneda M.
  • Journal Title: Nuclear Medicine and Biology. 印刷中
  • Peer Reviewed
• [Journal Article] Evaluation of striatal oxidative stress in patients with Parkinson's disease using [^<62>Cu]ATSM PET (2011)
  • Author(s): 井川正道, 他
  • Journal Title: Nuclear Medicine and Biology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Abnormal myocardial energy-production state in mitochondrial cardiomyopathy and acute response to L-arginine infusion : C-11 acetate kinetics revealed by positron emission tomography. (2010)
  • Author(s): Arakawa K, Kudo T, Ikawa M, Morikawa N, Kawai Y, Sahashi K, Lee JD, Kuriyama M, Miyamori I, Okazawa H, Yoneda M.
  • Journal Title: Circulation Journal. 74巻 Pages: 2702-2711
  • NAID: 10027424699
  • Peer Reviewed
• [Journal Article] Energy States in Mitochondrial Cardiomyopathy-In vivo Functional Imaging and L-arginine Therapy-[Editorial]. (2010)
  • Author(s): Ikawa M, Yoneda M, Tanaka M.
  • Journal Title: Circulation Journal. 74巻 Pages: 2560-2561
  • Peer Reviewed
• [Journal Article] Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images. (2010)
  • Author(s): Tsujikawa T, Yoneda M, Shimizu Y, Uematsu H, Toyooka M, Ikawa M, Kudo T, Okazawa H, Kuriyama M, Kimura H.
  • Journal Title: Brain & Development. 32巻 Pages: 143-149
  • NAID: 10027213011
  • Peer Reviewed
• [Journal Article] Abnormal myocardial energy-production state in mitochondrial cardiomyopathy and acute response to L-arginine infusion : C-11 acetate kinetics revealed by positron emission tomography (2010)
  • Author(s): 荒川健一郎, 井川正道, 他
  • Journal Title: Circulation Journal Volume: 74 Pages: 2702-2711
  • NAID: 10027424699
  • Peer Reviewed
• [Journal Article] Energy States in Mitochondrial Cardiomyopathy-In vivo Functional Imaging- and L-arginine Therapy- (2010)
  • Author(s): 井川正道, 他
  • Journal Title: Circulation Journal Volume: 74 Pages: 2560-2561
  • NAID: 10027424125
  • Peer Reviewed
• [Journal Article] PET imaging of redox and energy states in stroke-like episodes of MELAS. (2009)
  • Author(s): Ikawa M, Okazawa H, Arakawa K, Kudo T, Kimura H, Fujibayashi Y, Kuriyama M, Yoneda M.
  • Journal Title: Mitochondrion. 9巻 Pages: 144-148
  • Peer Reviewed
• [Journal Article] PET imaging of redox and energy states in stroke-like episodes of MELAS (2009)
  • Author(s): 井川正道
  • Journal Title: Mitochondrion 9 Pages: 144-148
  • Peer Reviewed
• [Presentation] In vivo functional imaging of energy states and a therapeutic potential of L-arginine for patients with mitochondrial cardiomyopathy. (2010)
  • Author(s): Ikawa M, Kudo T, Arakawa K, Kawai Y, Tsuchida T, Kuriyama M, Okazawa H, Tanaka M, Yoneda M.
  • Organizer: 7th Annual Meeting of ASMRM and 10th J-mit.
  • Place of Presentation: 福岡
  • Year and Date: 2010-12-16
• [Presentation] Cu-ATSM is a novel indicator of intercellular over-reduced states in mitochondrial dysfunction : fundamental evaluation using mitochondrial DNA-less (ρ0) cells and cybrids carrying causal mitochondrial DNA mutation of MELAS syndrome. (2010)
  • Author(s): Kuroda Y, Yoshii Y, Yoneda M, Ikawa M, Kiyono Y, Mori T, Yoshii H, Furukawa T, Asai T, Okazawa H, Fujibayashi Y.
  • Organizer: 7th Annual Meeting of ASMRM and 10th J-mit.
  • Place of Presentation: 福岡
  • Year and Date: 2010-12-16
• [Presentation] 62Cu-ATSM PET demonstrates increase of striatal oxidative stress in patients with Parkinson's disease. (2010)
  • Author(s): Ikawa M, Okazawa H, Kudo T, Kuriyama M, Fujibayashi Y, Yoneda M.
  • Organizer: EANM'10-Annual Congress of the European Association of Nuclear Medicine.
  • Place of Presentation: ウィーン(オーストリア)
  • Year and Date: 2010-10-10
• [Presentation] ^<62>Cu-ATSM PET demonstrates increase of striatal oxidative stress in patients with Parkinson's disease (2010)
  • Author(s): 井川正道, 他
  • Organizer: European Association of Nuclear Medicine
  • Place of Presentation: ウィーン(オーストリア)
  • Year and Date: 2010-10-10
• [Presentation] [62Cu]ATSM PET Demonstrates Increase of Striatal Oxidative Stress in Patients with Parkinson's Disease. (2010)
  • Author(s): Ikawa M, Okazawa H, Kudo T, Kuriyama M, Fujibayashi Y, Yoneda M.
  • Organizer: World Molecular Imaging Congress 2010.
  • Place of Presentation: 京都
  • Year and Date: 2010-09-09
• [Presentation] [^<62>Cu]ATSM PET Demonstrates Increase of Striatal Oxidative Stress in Patients with Parkinson's Disease (2010)
  • Author(s): 井川正道, 他
  • Organizer: World Molecular Imaging Congress
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-09-09
• [Presentation] パーキンソン病患者線条体における酸化ストレスのPETイメージング (2010)
  • Author(s): 井川正道, 岡沢秀彦, 工藤崇, 栗山勝, 藤林靖久, 米田誠
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-20
• [Presentation] Functional imaging of oxidative stress in the nigrostriatal system of patients with Parkinson's disease by 62Cu-ATSM-PET. (2010)
  • Author(s): Ikawa M, Okazawa H, Kudo T, Kuriyama M, Fujibayashi Y, Yoneda M.
  • Organizer: FUKUI 2010, International Conference on Brain Function and Development.
  • Place of Presentation: 福井
  • Year and Date: 2010-01-25
• [Presentation] Pathophysiologic evaluation of stroke-like episodes in MELAS patients by MRI and PET. (2010)
  • Author(s): Yoneda M, Ikawa M, Tsujikawa T, Arakawa K, Kudo T, Fujibayashi Y, Kimura H, Okazawa H, Kuriyama M.
  • Organizer: FUKUI 2010, International Conference on Brain Function and Development.
  • Place of Presentation: 福井
  • Year and Date: 2010-01-25
• [Presentation] Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images. (2010)
  • Author(s): Tsujikawa T, Yoneda M, Uematsu H, Toyooka M, Ikawa M, Kudo T, Okazawa H, Kuriyama M, Kimura H.
  • Organizer: FUKUI 2010, International Conference on Brain Function and Development.
  • Place of Presentation: 福井
  • Year and Date: 2010-01-25
• [Presentation] Functional imaging of oxidative stress in the nigrostriatal system of patients with Parkinson's disease by ^<62>Cu-ATSM-PET (2010)
  • Author(s): 井川正道
  • Organizer: International Conference on Brain Function and Development
  • Place of Presentation: ホテルフジタ(福井県)
  • Year and Date: 2010-01-25
• [Presentation] Pathophysiologic evaluation of cerebral blood flow, energy status and oxidative stress during stroke-like episodes in MELAS patients by MRI and PET. (2009)
  • Author(s): Ikawa M, Tsujikawa T, Arakawa K, Kudo T, Fujibayashi Y, Kimura H, Okazawa H, Kuriyama M, Yoneda M.
  • Organizer: The 6th Conference of Asian Society for Mitochondrial Research and Medicine.
  • Place of Presentation: 台北(台湾)
  • Year and Date: 2009-10-30
• [Presentation] Imaging of oxidative stress in the nigrostriatal system of patients with Parkinson's disease using 62Cu-ATSM-PET. (2009)
  • Author(s): Ikawa M, Okazawa H, Kudo T, Kuriyama M, Fujibayashi Y, Yoneda M.
  • Organizer: The 6th Conference of Asian Society for Mitochondrial Research and Medicine.
  • Place of Presentation: 台北(台湾)
  • Year and Date: 2009-10-30
• [Presentation] Imaging of oxidative stress in the nigrostriatal system of patients with Parkinson's disease using 62Cu-ATSM-PET (2009)
  • Author(s): 井川正道
  • Organizer: 6th Conference of Asian Society for Mitochondrial Research and Medicine
  • Place of Presentation: 台北医科大学(台湾)
  • Year and Date: 2009-10-30
• [Presentation] MELAS脳卒中様発作のMRI(CASL)・MRSによる血流・代謝の経時的変化の検討 (2009)
  • Author(s): 井川正道, 辻川哲也, 清水幸生, 植松秀昌, 豊岡麻理子, 工藤崇, 岡沢秀彦, 栗山勝, 木村浩彦, 米田誠
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-21
• [Presentation] パーキンソン病患者における線条体の酸化ストレスイメージング (2009)
  • Author(s): 井川正道, 岡沢秀彦, 工藤崇, 福村利光, 栗山勝, 藤林靖久, 米田誠
  • Organizer: 第4回日本分子イメージング学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-14
• [Presentation] パーキンソン病患者における線条体の酸化ストレスイメージング (2009)
  • Author(s): 井川正道
  • Organizer: 第4回日本分子イメージング学会学術集会
  • Place of Presentation: 学術総合センター(東京都)
  • Year and Date: 2009-05-14