A mechanisms of composing anti-aquaporin-4 antibody and the association with bacterial infection.
| Project/Area Number |
21790842
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 多発性硬化症 / 視神経脊髄炎 / アクアポリン4 / 細菌 |
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| Research Abstract |
We revealed influences of infectious status, genetic background and cytokine/chemokine profile on multiple sclerosis (MS) and neuromyelitis optica (NMO), especially on the production of anti aquaporin-4 (AQP4) antibody. Helicobacter pylori infection was more common in patients with anti-AQP4 antibody than in patients with conventional MS. Anti-NAP antibody titer positively correlated with the severity of neurological disability and patients with anti-NAP antibody had higher activity of myeloperoxidase than patients without the antibody. A frequency of HLA-DPB1*0501 was higher in patients with anti-AQP4 antibody than in healthy controls. Among HLA-DRB1 genotypes, HLA-DRB1*12 increased the risk of anti-AQP4 antibody-positivity. Individuals with HLA-DRB1*09/15 decreased the risk of anti-AQP4 antibody-negative MS, while those with HLA-DRB1*12/15 increased the risk of anti-AQP4 antibody-positivity. Patients with NMO had a higher concentration of IL-6, 8, 17, and IP-10 in CSF than patients with MS had. The value of IL-6, 8, and GCSF positively correlated with EDSS at sample collection, neutrophil count in CSF, and the value of IL-8 and GCSF had a positive correlation with the length of spinal cord lesions.
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Report
(3 results)
Research Products
(67 results)
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[Journal Article] Induction of paranodal myelin detachment and sodium channel loss in vivo by Campylobacter jejuni DNA-binding protein from starved cells (C-Dps) in myelinated nerve fibers.2010
Author(s)
Piao H, Minohara M, Kawamura N, Li W, Mizunoe Y, Umehara F, Goto Y, Kusunoki S, Matsushita T, Ikenaka K, Maejima T, Nabekura J, Yamasaki R, Kira J
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Journal Title
J Neurol Sci Both authors contributed equally 288
Pages: 54-62
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[Journal Article] Reappraisal of brain MRI features in patients with multiple sclerosis and neuromyelitis optica according to anti-aquaporin-4 antibody status.2010
Author(s)
Matsushita T, Isobe N, Piao H, Matsuoka T, Ishizu T, Doi H, Masaki K, Yoshimura T, Yamasaki R, Ohyagi Y, Kira J
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Journal Title
J Neurol Sci 291
Pages: 37-43
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[Presentation] Extensive Aquaporin-4 (AQP4) Loss In Balo's Concentric Sclerosis In The Absence Of Anti-AQP4 Antibody.2010
Author(s)
Masaki K, Matsuoka T, Suzuki SO, Wu XM, Zhang KN, Yonekawa T, Isobe N, Ordinario AT, Tabira T, Iwaki T, Matsushita T, Kira J
Organizer
PACTRIMS
Place of Presentation
Indonesia(口演)
Related Report
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[Presentation] Extensive Aquaporin-4 (AQP4) Loss in Balo's Concentric Sclerosis in The Absence of Anti-AQP4 Antibody.2010
Author(s)
Masaki K, Matsuoka T, Suzuki SO, Wu XM, Zhang KN, Yonekawa T, Isobe N, Ordinario AT, Tabira T, Iwaki T, Matsushita T, Kira J
Organizer
PACTRIMS
Place of Presentation
Indonesia
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