| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We revealed influences of infectious status, genetic background and cytokine/chemokine profile on multiple sclerosis (MS) and neuromyelitis optica (NMO), especially on the production of anti aquaporin-4 (AQP4) antibody. Helicobacter pylori infection was more common in patients with anti-AQP4 antibody than in patients with conventional MS. Anti-NAP antibody titer positively correlated with the severity of neurological disability and patients with anti-NAP antibody had higher activity of myeloperoxidase than patients without the antibody. A frequency of HLA-DPB1*0501 was higher in patients with anti-AQP4 antibody than in healthy controls. Among HLA-DRB1 genotypes, HLA-DRB1*12 increased the risk of anti-AQP4 antibody-positivity. Individuals with HLA-DRB1*09/15 decreased the risk of anti-AQP4 antibody-negative MS, while those with HLA-DRB1*12/15 increased the risk of anti-AQP4 antibody-positivity. Patients with NMO had a higher concentration of IL-6, 8, 17, and IP-10 in CSF than patients with MS had. The value of IL-6, 8, and GCSF positively correlated with EDSS at sample collection, neutrophil count in CSF, and the value of IL-8 and GCSF had a positive correlation with the length of spinal cord lesions.
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