| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We identified that caspase-3 generates two 35-kDa and 25-kDa fragments under the apoptotic condition. However, novel caspase-3-independent isoforms of these two variants were also detected under normal conditions. The 35-kDa fragment expression led to the formation of stress granules, while aggresomes were formed in the cytoplasm of cells expressing 35-kDa fragment in the presence of proteasome inhibitors.
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