| Project/Area Number |
21790853
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
SAIKI Shinji Juntendo University, 医学部, 助手 (00339996)
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| Co-Investigator(Renkei-kenkyūsha) |
HATTORI Nobutaka 順天堂大学, 医学部, 教授 (80218510)
SATO Shigeto 順天堂大学, 医学部, 准教授 (00445537)
HATANO Taku 順天堂大学, 医学部, 助教 (60338390)
EGUCHI Hiroto 順天堂大学, 医学部, 助教 (20380868)
IMOTO Masaya 慶應義塾大学, 理工学部, 教授 (60213253)
TANIDA Isei 国立感染症研究所, 主任研究員 (30296868)
MATSUDA Noriyuki 東京都臨床医学総合研究所, 研究員 (10332272)
KOMATSU Masaaki 東京都臨床医学総合研究所, 参事研究員 (90356254)
TANAKA Keiji 東京都臨床医学総合研究所, 所長代行 (10108871)
AMO Taku 防衛大学, 校応用化学群, 助教 (40453922)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | オートファジー / パーキンソン病 / ミトファジー |
|---|
| Research Abstract |
PINK1/parkin-mediated mitophagy is attenuated by loss of each gene expression and pathogenic mutations of the genes and is triggered by PINK1 accumulation on the mitochondrial outer membrane. In PINK1-/- mouse embryonic fibroblasts, mitochondrial function is insufficient, whilst production of the reactive oxygen species is unchanged.
Caffeine, a well-known chemical with PD-onset retardation effects, induces apoptosis via enhancement of autophagy. Zonisamide prevents cell death via suppression of apoptotic pathway and induction of MnSOD expression.
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