Regulatory mechanisms of lipin, a multifunctional metabolic regulator, and its therapeutic application for metabolic diseases
| Project/Area Number |
21790857
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
TAKAHASHI Nobuhiko Asahikawa Medical College, 歯学部, 准教授 (20372279)
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| Research Collaborator |
TSUCHIYA Yoshihiro 旭川医科大学, 医学部, 医員 (00516990)
YOSHIZAKI Takayuki 鹿児島大学, 産学官連携推進機構, 特任講師 (70515189)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脂肪細胞 / メタボリックシンドローム / Lipin |
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| Research Abstract |
Lipin-1 is known as a multifunctional metabolic regulator. The gene expression of lipin-1 in adipocytes is closely related to whole body glucose metabolism, but the mechanism remains unclear. Here, we showed that TNF-α suppressed lipin-1 mRNA expression via Jak2 signal in 3T3-L1 adipocytes. Moreover, suppression of lipin-1 expression using RNAi method increases monocyte chemoattractant protein-1 mRNA expression in the adipocytes. We conclude that lipin-1 is implicated in one of crucial molecules related to adipose tissue inflammation.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] A Jak2 inhibitor, AG490, reverses lipin-1 suppression by INF-α in 313-L1 adipocytes2009
Author(s)
Tsuchiya Y, Takahashi N, Yoshizaki T, Tanno S, Ohhira M, Motomua W, Tanno S, Takakusaki K, Kohgo Y, Okumura T.
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Journal Title
Biochem.Biophys.Res.Commun. Vo.382
Pages: 348-352
Related Report
Peer Reviewed
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