The role of fatty acid elongation enzyme Elovl6 through cannabinoid receptor in a hippocampus

• Project/Area Number: 21790860
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: University of Tsukuba
• Principal Investigator: ISHII Kiyoaki University of Tsukuba, 大学院・人間総合科学研究科, 助教 (80419150)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: カンナビノイド / エネルギー代謝 / 脂質 / 海馬

Research Abstract

Influence to proliferation and differentiation was observed by a glia cell and a nerve cell of Elovl6 KO mouse hippocampus. Because 2-AG amount of the endogenous cannabinoid receptor agonist decreases by a hippocampus of KO mouse, a possibility that cannabinoid cascade through 2-AG can consider.

Research Products

• [Journal Article] The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha. (2010)
  • Author(s): Danno H, Ishii KA, Nakagawa Y, Mikami M, Yamamoto T, Yabe S, Furusawa M, Kumadaki S, Watanabe K, Shimizu H, Matsuzaka T, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Yamada N, Shimano H.
  • Journal Title: Biochemical and biophysical research communications 391(2) Pages: 1222-1227
  • Peer Reviewed
• [Journal Article] The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha (2010)
  • Author(s): Danno H, Ishii KA, Nakagawa Y, Mikami M, Yamamoto T, Yabe S, Furusawa M, et al.
  • Journal Title: Biochemical and biophysical research communications 391(2) Pages: 1222-1227
  • Peer Reviewed
• [Journal Article] The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice. (2009)
  • Author(s): Nakanishi N, Nakagawa Y, Tokushige N, Aoki N, Matsuzaka T, Ishii K, Yahagi N, Kobayashi K, Yatoh S, Takahashi A, Suzuki H, Urayama O, Yamada N, Shimano H.
  • Journal Title: Biochemical and biophysical research communications 385(4) Pages: 492-496
  • Peer Reviewed
• [Journal Article] PGC-1βと鉄の協調作用による破骨細胞の活性化 (2009)
  • Author(s): 石井清朗、池田恭治
  • Journal Title: 細胞工学 28 Pages: 584-585
• [Journal Article] The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice (2009)
  • Author(s): Nakanishi N, Nakagawa Y, Tokushige N, Aoki N, Matsuzaka T, Ishii K, et al.
  • Journal Title: Biochemical and biophysical research communications 385(4) Pages: 492-496
  • Peer Reviewed
• [Presentation] ミトコンドリア生合成と破骨細胞活性化におけるPGC-1βと鉄取り込みの協調作用 (2009)
  • Author(s): 石井清朗
  • Organizer: 細胞シグナル時空間制御機構研究会
  • Place of Presentation: 東京大学
  • Year and Date: 2009-04-25
• [Remarks]
  • URL: http://www.u-tsukuba-endocrinology.jp/
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/clinical-med/endocrinology/research/