The roles of transcription factor FoxO1 in pancreatic β cell proliferation and neogenesis

Research Project

Project/Area Number	21790862
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Metabolomics
Research Institution	Gunma University
Principal Investigator	KOBAYASHI Masaki Gunma University, 生体調節研究所, 助教 (80373041)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	糖尿病 / 膵臓 / 生理学
Research Abstract	In present study, we analyze the characters of pancreas-specific (P-FoxO1-KO) and β cell-specific FoxO1 knockout mice (β-FoxO1-KO) under two different conditions, high fat high sucrose diet and db/db background, to investigate the physiological roles of FoxO1 in the pancreas in vivo. We conclude that FoxO1 functions as a double-edged sword in the pancreas ; FoxO1 essentially inhibits β cell neogenesis but is required for the maintenance of insulin secretion under metabolic stress

Report

(3 results)