| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Research Abstract |
We investigated whether WTAP contributes to the progression of obesity or diabetes. Wtap+/- mice were smaller in body weight and body fat contents fed on both normal chow and high fat diet, and more glucose tolerant and insulin sensitive than wild type (WT) mice. Both in vivo and in vitro studies showed the new roles of WTAP in development of obesity and diabetes by affecting adipose tissue, liver and macrophage.
|
