Roles of Wilms' Tumor 1-Associating Protein in Development of Obesity and Diabetes
| Project/Area Number |
21790866
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKAZAKI Yukiko The University of Tokyo, 医学部附属病院, 助教 (30422299)
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Masatoshi 東京大学, 大学院・医学系研究科, 特任研究員 (30396725)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | エネルギー・糖質代謝異常 / 脂肪組織 |
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| Research Abstract |
We investigated whether WTAP contributes to the progression of obesity or diabetes. Wtap+/- mice were smaller in body weight and body fat contents fed on both normal chow and high fat diet, and more glucose tolerant and insulin sensitive than wild type (WT) mice. Both in vivo and in vitro studies showed the new roles of WTAP in development of obesity and diabetes by affecting adipose tissue, liver and macrophage.
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Report
(3 results)
Research Products
(16 results)
