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Roles of Wilms' Tumor 1-Associating Protein in Development of Obesity and Diabetes

Research Project

Project/Area Number 21790866
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionThe University of Tokyo

Principal Investigator

OKAZAKI Yukiko  The University of Tokyo, 医学部附属病院, 助教 (30422299)

Co-Investigator(Renkei-kenkyūsha) KOBAYASHI Masatoshi  東京大学, 大学院・医学系研究科, 特任研究員 (30396725)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsエネルギー・糖質代謝異常 / 脂肪組織
Research Abstract

We investigated whether WTAP contributes to the progression of obesity or diabetes. Wtap+/- mice were smaller in body weight and body fat contents fed on both normal chow and high fat diet, and more glucose tolerant and insulin sensitive than wild type (WT) mice. Both in vivo and in vitro studies showed the new roles of WTAP in development of obesity and diabetes by affecting adipose tissue, liver and macrophage.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2010 2009

All Presentation (16 results)

  • [Presentation] Wilms' tumor 1-associating protein阻害による抗肥満・抗糖尿病の可能性2010

    • Author(s)
      小林正稔、岡崎由希子、植木浩二郎
    • Organizer
      第3回日本肥満症治療学会
    • Place of Presentation
      学術総合センター(東京)
    • Year and Date
      2010-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Wilms' tumor 1-associating protein阻害による抗肥満・抗糖尿病の可能性2010

    • Author(s)
      小林正稔, 岡崎由希子
    • Organizer
      第3回 日本肥満症治療学会
    • Place of Presentation
      学術総合センター(東京)
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Roles of Wilms' Tumor- 1-Associating Protein in Development of Obesity and Diabetes2010

    • Author(s)
      小林正稔、岡崎由希子、植木浩二郎
    • Organizer
      第70回米国糖尿病学会
    • Place of Presentation
      Orange County Convention Center(オークランド・米国)
    • Year and Date
      2010-06-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Roles of Wilms' Tumor 1-Associating Protein in Development of Obesity and Diabetes2010

    • Author(s)
      小林正稔, 岡崎由希子
    • Organizer
      第70回 米国糖尿病学会
    • Place of Presentation
      Orange County Convention Center(オーランド・米国)
    • Year and Date
      2010-06-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Wilms' tumor 1-associating protein(WTAP)の肥満・糖代謝への関与の検討2010

    • Author(s)
      小林正稔、岡崎由希子、植木浩二郎
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      、岡山コンベンションセンター(岡山)
    • Year and Date
      2010-05-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Wilms' tumor 1-associating protein(WTAP)の肥満・糖代謝への関与の検討2010

    • Author(s)
      小林正稔, 岡崎由希子
    • Organizer
      第53回 日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Wilms' tumor 1-associating protein の肥満・糖代謝への関与の検討2010

    • Author(s)
      小林正稔、岡崎由希子、植木浩二郎
    • Organizer
      第83回日本内分泌学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Wilms' tumor 1-associating protein の肥満・糖代謝への関与の検討2010

    • Author(s)
      小林正稔、岡崎由希子、植木浩二郎
    • Organizer
      第24回日本肥満・糖尿病動物学会
    • Place of Presentation
      ホテルコスモスクエア国際交流センター(大阪)
    • Year and Date
      2010-01-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Wilms' tumor 1-associating protein の肥満・糖代謝への関与の検討2009

    • Author(s)
      小林正稔、岡崎由希子、植木浩二郎
    • Organizer
      第59回日本体質医学会
    • Place of Presentation
      学士会館(東京)
    • Year and Date
      2009-07-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Wilms' tumor 1-associating protein の肥満・糖代謝への関与の検討2009

    • Author(s)
      小林正稔、岡崎由希子、大杉満、植木浩二郎、門脇孝
    • Organizer
      日本体質医学会
    • Place of Presentation
      (学士会館)東京
    • Year and Date
      2009-07-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Wilms' tumor 1-associating protein の肥満・糖代謝への関与の検討2009

    • Author(s)
      小林正稔、岡崎由希子、植木浩二郎
    • Organizer
      第2回日本肥満症治療学会
    • Place of Presentation
      日本消防会館(東京)
    • Year and Date
      2009-07-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Wilms' tumor 1-associating protein の肥満・糖代謝への関与の検討2009

    • Author(s)
      小林正稔、岡崎由希子、大杉満、植木浩二郎、門脇孝
    • Organizer
      日本肥満症治療学会
    • Place of Presentation
      (日本消防会舘)東京
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Wilms' tumor 1-associating protein の肥満・糖代謝への関与の検討2009

    • Author(s)
      小林正稔、岡崎由希子、植木浩二郎
    • Organizer
      第52回日本糖尿病学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-05-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Wilms' tumor 1-associating protein の肥満・糖代謝への関与の検討2009

    • Author(s)
      小林正稔、岡崎由希子、大杉満、植木浩二郎、門脇孝
    • Organizer
      日本糖尿病学会
    • Place of Presentation
      (大阪国際会議場)大阪
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Wilms' tumor 1-associating protein の肥満・糖代謝への関与の検討2009

    • Author(s)
      小林正稔、岡崎由希子、大杉満、植木浩二郎、門脇孝
    • Organizer
      日本内分泌学会
    • Place of Presentation
      (国立京都国際会館)京都
    • Year and Date
      2009-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Wilms' tumor 1-associating protein の肥満・糖代謝への関与の検討2009

    • Author(s)
      小林正稔、岡崎由希子、大杉満、植木浩二郎、門脇孝
    • Organizer
      日本肥満・糖尿病動物学会
    • Place of Presentation
      (ホテルコスモスクエア国際交流センター)大阪
    • Year and Date
      2009-01-22
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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