| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
SRT1720 treatment suppressed JNK signaling pathway, activated in white adipose tissue of high fat-fed mice. We constructed monocyte/macrophage specific SIRT1 knock out mice and fed high fat diet. In white adipose tissue of high fat-fed monocyte/macrophage specific SIRT1 knock out mice, inflammatory and hypoxia related genes were up-regulated compared with control mice. In conclusion, SIRT1 activation in macrophage was suggested to suppress inflammatory reaction in white adipose tissue of obese model.
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