Investigation of the role of cell-cycle regulatory mechanism in hepatic glucose metabolism
| Project/Area Number |
21790868
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Kanazawa University |
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Principal Investigator |
INOUE Hiroshi Kanazawa University, フロンティアサイエンス機構, 特任准教授 (50397832)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 肝糖新生 / 細胞周期 / Cyclin D1 / STAT3 |
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| Research Abstract |
Cyclin D1 is known to regulate not only cell-cycle but also activity of various transcription factors. Through this investigation, we have uncoverd an alteration in hepatic cyclin D1 expression by fasting and refeeding. Fasting reduced the expression of cyclin D1 gene and protein and refeeding increased. We have also clarified that cyclin D1 suppressed the promoter activity of gluconeogenic gene in H42E hepatoma cell. These results suggest that hepatic cyclin D1 would plays a certain role in the regulation of glucose metabolism.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action.2010
Author(s)
Takashima M, Ogawa W, Hayashi K, Inoue H, Kinoshita S, Okamoto Y, Sakaue H, Wataoka Y, Emi A, Senga Y, Matsuki Y, Watanabe E, Hiramatsu R, Kasuga M.
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Journal Title
Diabetes. 59(7)
Pages: 1608-15
Related Report
Peer Reviewed
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[Journal Article] Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice.2010
Author(s)
Matsuda T, Kido Y, Asahara SI, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M,Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M.
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Journal Title
J Clin Invest. 120(1)
Pages: 115-126
Related Report
Peer Reviewed
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