Investigation of the role of cell-cycle regulatory mechanism in hepatic glucose metabolism

• Project/Area Number: 21790868
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Kanazawa University
• Principal Investigator: INOUE Hiroshi Kanazawa University, フロンティアサイエンス機構, 特任准教授 (50397832)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 肝糖新生 / 細胞周期 / Cyclin D1 / STAT3

Research Abstract

Cyclin D1 is known to regulate not only cell-cycle but also activity of various transcription factors. Through this investigation, we have uncoverd an alteration in hepatic cyclin D1 expression by fasting and refeeding. Fasting reduced the expression of cyclin D1 gene and protein and refeeding increased. We have also clarified that cyclin D1 suppressed the promoter activity of gluconeogenic gene in H42E hepatoma cell. These results suggest that hepatic cyclin D1 would plays a certain role in the regulation of glucose metabolism.

Research Products

• [Journal Article] 中枢神経インスリン作用による肝糖産生制御機構 (2011)
  • Author(s): 井上啓
  • Journal Title: 実験医学 29(5) Pages: 773-778
• [Journal Article] 中枢神経インスリン作用による肝糖産生制御機構 (2011)
  • Author(s): 井上啓
  • Journal Title: 実験医学 Volume: 29 Pages: 773-778
• [Journal Article] Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action. (2010)
  • Author(s): Takashima M, Ogawa W, Hayashi K, Inoue H, Kinoshita S, Okamoto Y, Sakaue H, Wataoka Y, Emi A, Senga Y, Matsuki Y, Watanabe E, Hiramatsu R, Kasuga M.
  • Journal Title: Diabetes. 59(7) Pages: 1608-15
  • Peer Reviewed
• [Journal Article] Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. (2010)
  • Author(s): Matsuda T, Kido Y, Asahara SI, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M,Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M.
  • Journal Title: J Clin Invest. 120(1) Pages: 115-126
  • Peer Reviewed
• [Journal Article] Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action. (2010)
  • Author(s): Takashima M.
  • Journal Title: Diabetes Volume: 59 Pages: 1608-1615
  • Peer Reviewed
• [Journal Article] Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. (2010)
  • Author(s): Matsuda T.
  • Journal Title: J Clin Invest. 120 Pages: 115-126
  • Peer Reviewed
• [Presentation] 小胞体ストレスは、アセチル化抑制を介して、STAT3 依存性の肝糖新生系酵素遺伝子発現抑制を阻害する (2010)
  • Author(s): 木村久美・井上啓
  • Organizer: 第22回分子糖尿病学シンポジウム
  • Place of Presentation: 東京カンファレンスセンター品川(東京都)
  • Year and Date: 2010-12-04
• [Presentation] 小胞体ストレスは脱アセチル化を介してSTAT3 依存性の肝糖新生酵素発現抑制を阻害する (2010)
  • Author(s): 木村久美・井上啓
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬県)
  • Year and Date: 2010-10-01
• [Presentation] 小胞体ストレスは脱アセチル化を介してSTAT3依存性の肝糖新生酵素発現抑制を阻害する (2010)
  • Author(s): 木村久美
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ(群馬)
  • Year and Date: 2010-10-01
• [Presentation] 小胞体ストレスはSTAT3依存性の肝糖新生酵素発現抑制を阻害する (2010)
  • Author(s): 井上啓
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山コンベンションセンター(岡山県)
  • Year and Date: 2010-05-27
• [Presentation] 小胞体ストレスはSTAT3依存性の肝糖新生酵素発現抑制を阻害する (2010)
  • Author(s): 井上啓
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山コンベンションセンター(岡山)
  • Year and Date: 2010-05-27
• [Presentation] STAT3依存性肝糖新生調節における小胞体ストレスの役割 (2010)
  • Author(s): 山田智子・井上啓
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 就実大学(岡山県)
  • Year and Date: 2010-03-28
• [Presentation] STAT3依存性肝糖新生調節における小胞体ストレスの役割 (2010)
  • Author(s): 山田智子
  • Organizer: 日本薬学会
  • Place of Presentation: 就実大学(岡山)
  • Year and Date: 2010-03-28
• [Remarks] ホームページ等
  • URL: http://inoue.w3.kanazawa-u.ac.jp/index.html
• [Remarks]
  • URL: http://inoue.w3.kanazawa-u.ac.jp/index.html