Development of newly insulin sensitizers via SIRT1

• Project/Area Number: 21790871
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Shiga University of Medical Science
• Principal Investigator: YOSHIZAKI Takeshi Shiga University of Medical Science, 医学部, 特任助教 (20510324)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: インスリン抵抗性 / 糖尿病 / メタボリック症候群 / SIRT1 / メタボリックシンドローム

Research Abstract

In macrophage and adipocyte, SIRT inhibited inflammatory responses accompany with improvement of insulin sensitivity. SIRT1 activator improved glucose intolerance and insulin sensitivity in obese Zucker Fatty rats. Pharmacological activation of SIRT1 may be a useful anti-inflammatoy therapeutic strategy for treating insulin resistance.

Research Products

• [Journal Article] Olefsky SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. (2010)
  • Author(s): Takeshi Yoshizaki, Simon Schenk, Takeshi Imamura, Jennie L.Babendure, Noriyuki Sonoda, Eun Ju Bae, Da Young Oh, Min Lu, Jill C.Milne, Christoph Westphal, Gautam Bnadyopadhyay, Jerrold M.
  • Journal Title: Am J Physiol Endocrinol Metab Vol298
  • Peer Reviewed
• [Journal Article] SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. (2010)
  • Author(s): 吉崎健
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 298
  • Peer Reviewed
• [Presentation] インスリン抵抗性におけるSIRT1の治療応用 (2011)
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-20
• [Presentation] インスリン抵抗性におけるSIRT1の治療応用 (2011)
  • Author(s): 吉崎健
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2011-05-20
• [Presentation] 脂肪組織におけるSIRT1のインスリン感受性改善機構にはマクロファージの質の変化も関与する (2010)
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-27
• [Presentation] 脂肪組織におけるSIRT1のインスリン感受性改善機構におマクロファージの質の変化も関与する。 (2010)
  • Author(s): 吉崎健
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山コンベンションセンター(岡山県)(発表予定)
  • Year and Date: 2010-05-27