| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Insulin is a hormone central to the maintenance of blood glucose levels. Following insulin release, the secretory membranes are taken up for another round of exocytosis. Although the recycling of the secretory membranes is crucial for insulin secretion, the precise molecular mechanisms have not been elucidated. In the present study, we revealed that GDP-Rab27a and its binding proteins regulate this process via cytoskeletal modulation. These molecules involved in the pathway may be a novel therapeutic target for diabetes mellitus.
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