Identification and characterization of the new therapy target for metabolic syndrome

• Project/Area Number: 21790879
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Saitama Medical University (2010); Jichi Medical University (2009)
• Principal Investigator: YOKOO Tomotaka Saitama Medical University, 医学部, 助教 (80400688)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 生活習慣病 / 糖尿病 / 遺伝子発現

Research Abstract

We identified and analyzed the gene related metabolic syndrome with unknown function. The PPARs controlled mitochondrial protein, mitoNEET was ameliorated a glucose metabolism, body weight and HbA1c in diabetic mice adenovirus mediated overexpression of the liver. Additionally, novel intestine specific secretory protein, IBCAP, was other candidate of metabolic syndrome relation factor as another potential therapeutic target for diabetes.

Research Products

• [Journal Article] Transgenic mice expressing an intestine-specific secretory protein, IBCAP, demonstrates pancreatic beta cell augmenting activity (2010)
  • Author(s): Yokoo T, Watanabe K, Iida KT, Suzuki H, Shimano H, Ishikawa S-E, Kawakami M, Okazaki Y, Yamada N, Toyoshima H
  • Journal Title: Diabetologia 53(Suppl1)
  • Peer Reviewed
• [Journal Article] Transgenic Mice Expressing an Intestine-Specific Secretory Protein, IBCAP (Formerly CF266), Demonstrates Pancreatic β-Cell Augmenting Activity. (2010)
  • Author(s): Yokoo T, Watanabe K, Iida KT, Suzuki H, Shimano H, Ishikawa S-E, Kawakami M, Yamada N, Toyoshima H
  • Journal Title: Endocrine Reviews 31(3) Suppl 1
  • Peer Reviewed
• [Journal Article] Transgenic Mice Expressing an Intestine-Specific Secretory Protein, IBCAP (Formerly CF266), Demonstrates Pancreatic ss-Cell Augmenting Activity. (2010)
  • Author(s): Tomotaka YOKOO
  • Journal Title: Endocrine Reviews Volume: 31(3) Suppl 1
  • Peer Reviewed
• [Journal Article] Transgenic mice expressing an intestine-specific secretory protein, IBCAP, demonstrates pancreatic beta cell augmenting activity (2010)
  • Author(s): Tomotaka YOKOO
  • Journal Title: Diabetologia Volume: 53(Suppl1)
  • Peer Reviewed
• [Journal Article] SPARC is a major secretory gene expressed and involved in the development of proliferative diabetic retinopathy. (2009)
  • Author(s): Watanabe K, Okamoto F, Yokoo T, Iida KT, Suzuki H, Ishikawa S, Kawakami M, Shimano H, Oshika T, Yamada N, Toyoshima H.
  • Journal Title: J Atheroscler Thromb. 16(2) Pages: 69-76
  • NAID: 10025764920
  • Peer Reviewed
• [Journal Article] Transgenic Mice Expressing an Intestine-Specific Secretory Protein, IMCAP (Formerly CF266), Demonstrates Pancreatic β-Cell Augmenting Activity. (2009)
  • Author(s): Yokoo T, Watanabe K, Tada-Iida K, Suzuki H, Shimano H, Ishikawa S-E, Kawakami M, Yamada N, Toyoshima H
  • Journal Title: Diabetes 58,Suppl(1)
  • Peer Reviewed
• [Journal Article] SPARC is a major secretory gene expressed and involved in the development of proliferative diabetic retinopathy. (2009)
  • Author(s): Kazuhisa WATANABE
  • Journal Title: J.Atheroscler.Thromb. Vol. 16(2) Pages: 69-76
  • Peer Reviewed
• [Presentation] インスリン分泌刺激作用を持つ新規消化管特異的分泌タンパクIBCAPの機能解析 (2010)
  • Author(s): 横尾友隆
  • Organizer: 第8回 RCGMフロンティア国際シンポジウム
  • Place of Presentation: 埼玉医科大学(埼玉県日高市)
  • Year and Date: 2010-11-03
• [Presentation] Transgenic mice expressing an intestine-specific secretory protein, IBCAP, demonstrates pancreatic beta cell augmenting activity. (2010)
  • Author(s): Tomotaka Yokoo, Kazuhisa Watanabe, Kaoruko Tada Iida, Hiroaki Suzuki, Hitoshi Shimano, San-e Ishikawa, Masanobu Kawakami, Nobuhiro Yamada, Yasushi Okazaki, Hideo Toyoshima.
  • Organizer: 46th EASD Annual Meeting
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-09-22
• [Presentation] Transgenic mice expressing an intestine-specific secretory protein, IBCAP demonstrates pancreatic beta cell augmenting activity. (2010)
  • Author(s): Tomotaka YOKOO
  • Organizer: 第46回 欧州糖尿病学会議(EASD)
  • Place of Presentation: STOCKHOLMSMASSAN(ストックホルム)(Sweden)
  • Year and Date: 2010-09-22
• [Presentation] Transgenic Mice Expressing an Intestine-Specific Secretory Protein, IBCAP (Formerly CF266), Demonstrates Pancreatic β-Cell Augmenting Activity. (2010)
  • Author(s): Tomotaka Yokoo, Kazuhisa Watanabe, Kaoruko Tada Iida, Hiroaki Suzuki, Hitoshi Shimano, San-e Ishikawa, Masanobu Kawakami, Nobuhiro Yamada, Hideo Toyoshima.
  • Organizer: ENDO 2010: The 92nd Annual Meeting & Expo
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-06-19
• [Presentation] Transgenic Mice Expressing an Intestine-Specific Secretory Protein, IBCAP (Formerly CF266), Demonstrates Pancreatic ss-Cell Augmenting Activity. (2010)
  • Author(s): Tomotaka YOKOO
  • Organizer: 第92回 米国内分泌学会年次集会(ENDO 2010)
  • Place of Presentation: San Diego Convention Center(サンディエゴ),(USA)
  • Year and Date: 2010-06-19
• [Presentation] Identification and Characterization of IBCAP, a Novel Intestine-specific Secretory Protein with Pancreatic Beta-cell Augmenting Activity. (2009)
  • Author(s): 横尾友隆、渡邊和寿、飯田薫子、鈴木浩明、島野仁、石川三衛、川上正舒、山田信博、豊島秀男
  • Organizer: 第32回日本分子生物学学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] Identification and Characterization of IBCAP, a Novel Intestine-specific Secretory Protein with Pancreatic Beta-cell Augmenting Activity. (2009)
  • Author(s): 横尾友隆
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-12-10
• [Presentation] Analysis of the nutritional regulation and the physiological role of ELOVL family member 5 (Elov15) (2009)
  • Author(s): 小安さおり
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-12-10
• [Presentation] 新規消化管特異的分泌タンパクIBCAPの機能解析 (2009)
  • Author(s): 横尾友隆、渡邊和寿、飯田薫子、鈴木浩明、島野仁、石川三衛、川上正舒、山田信博、豊島秀男
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] 新規消化管特異的分泌タンパクIBCAPの機能解析 (2009)
  • Author(s): 横尾友隆
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2009-10-23
• [Presentation] 脂肪酸伸長酵素Elov15の発現制御機構および生理的機能の解析 (2009)
  • Author(s): 小安さおり
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2009-10-22
• [Presentation] Transgenic Mice Expressing an Intestine-Specific Secretory Protein, IBCAP (Formerly CF266), Demonstrates Pancreatic β-Cell Augmenting Activity. (2009)
  • Author(s): Tomotaka Yokoo, Kazuhisa Watanabe, Kaoruko Tada Iida, Hiroaki Suzuki, Hitoshi Shimano, San-e Ishikawa, Masanobu Kawakami, Nobuhiro Yamada, Hideo Toyoshima.
  • Organizer: The 69th Scientific Sessions of America Diabetes Association
  • Place of Presentation: New Orleans
  • Year and Date: 2009-06-08
• [Presentation] Transgenic Mice Expressing an Intestine-Specific Secretory Protein, IBCAP (Formerly CF266), Demonstrates Pancreatic β-Cell Augmenting Activity. (2009)
  • Author(s): Tomotaka YOKOO
  • Organizer: 第69回アメリカ糖尿病学会学術大会
  • Place of Presentation: Morial Convention Center(ニューオリンズ)
  • Year and Date: 2009-06-08
• [Presentation] 膵β細胞増加作用を持つ新規消化管特異的分泌タンパクIBCAPの解析 (2009)
  • Author(s): 横尾友隆、渡邊和寿、飯田薫子、鈴木浩明、島野仁、石川三衛、川上正舒、山田信博、豊島秀男
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-23
• [Presentation] 膵β細胞増加作用を持つ新規消化管特異的分泌タンパクIBCAPの解析 (2009)
  • Author(s): 横尾友隆
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2009-05-23
• [Presentation] 膵β細胞増加作用を持つ新規消化管特異的分泌タンパクIBCAPの解析 (2009)
  • Author(s): 豊島秀男、横尾友隆、渡邊和寿、飯田薫子、鈴木浩明、島野仁、石川三衛、川上正舒、山田信博
  • Organizer: 第82回日本内分泌学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2009-04-23
• [Presentation] 膵β細胞増加作用を持つ新規消化管特異的分泌タンパクIBCAPの解析 (2009)
  • Author(s): 豊島秀男
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 群馬県民会館(前橋)
  • Year and Date: 2009-04-23