the hepatic immune therapy for metabolic disease

• Project/Area Number: 21790882
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Keio University
• Principal Investigator: IRIE Junichiro 慶應義塾大学, 医学部, 助教 (70306687)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 糖尿病 / 脂肪肝 / 免疫

Research Abstract

NAFLD(nonalcoholic fatty liver disease) is recently recognized as not only the consequence but also the cause of metabolic disorders, but the precise mechanisms of NAFLD remain unclear. Here we have shown that the immune systems are essential for the development of NAFLD and the cytokines could be the therapeutic targets of NAFLD leading to the improvement of metabolic syndromes.

Research Products

• [Journal Article] The Role of Hepatic T Lymphocytes in the Induction of Fatty Liver and Diabetes (2011)
  • Author(s): Hirotsune Tagawa, Junichiro Irie, Arata Itoh, Yukie Soeda, Satoru Yamada, Hiroshi Itoh
  • Journal Title: Clinical and Experimental Hypertension Volume: 33(1) Pages: 15-15
  • Peer Reviewed
• [Presentation] 肝脂肪蓄積・糖脂質代謝異常を引き起こす肝内Tリンパ球の検討 (2011)
  • Author(s): 伊藤新, 入江潤一郎, 田川裕恒, 加藤麻里, 添田幸恵, 山田悟, 伊藤裕
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-21
• [Presentation] 肝脂肪蓄積・糖脂質代謝異常を引き起こす肝内Tリンパ球分画の検討 (2011)
  • Author(s): 伊藤新
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌市教育文化会館(北海道)
  • Year and Date: 2011-05-21
• [Presentation] 肝内免疫担当細胞の制御による肝脂肪化と糖脂質代謝の調節 (2010)
  • Author(s): 伊藤新, 入江潤一郎, 田川裕恒, 添田幸恵, 伊藤裕
  • Organizer: 第53回日本糖尿病学会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-29
• [Presentation] 肝内免疫担当細胞の制御による肝脂肪化と糖脂質代謝の調節 (2010)
  • Author(s): 伊藤新
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-29
• [Presentation] 消化管・腸内環境を介した糖尿病、メタボリックシンドロームの治療 (2010)
  • Author(s): 入江潤一郎
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-26
• [Presentation] Tリンパ球の糖脂質代謝・肝脂肪蓄積への影響の検討 (2009)
  • Author(s): 田川裕恒、入江潤一郎、伊藤新、添田幸恵、山田悟、伊藤裕
  • Organizer: 第45回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-05
• [Presentation] Tリンパ球の糖脂質代謝・肝脂肪蓄積への影響 (2009)
  • Author(s): 田川裕恒
  • Organizer: 第45回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-05
• [Presentation] Tリンパ球の糖脂質代謝への影響の検討 (2009)
  • Author(s): 田川裕恒、入江潤一郎、伊藤新、添田幸恵、山田悟、伊藤裕
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-23
• [Presentation] Tリンパ球の糖脂質代謝への影響の検討 (2009)
  • Author(s): 田川裕恒
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-23