Investigation of vascular smooth muscle proliferation by glucose fluctuation

Research Project

Project/Area Number	21790883
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Metabolomics
Research Institution	Juntendo University
Principal Investigator	NOMIYAMA Takashi Juntendo University, 医学部, 助教 (10532559)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	エネルギー / 糖質代謝異常 / 糖尿病 / 血管平滑筋増殖 / GLP-1 / 新生内膜形成 / 血糖変動 / 血管平滑筋細胞増殖
Research Abstract	Diabetes is a risk factor for atherosclerosis and the prevention of atherosclerosis is very important. We investigated the effects of GLP-1 receptor agonists (Ex-4) on vascular smooth muscle cells. Ex-4 attenuated neointimal formation after wire injury in mice. We demonstrated that the decrease in smooth muscle cell proliferation with Ex-4 may contribute the prevention of atherosclerosis. These unique effects of GLP-1R agonist may help design new therapies for cardiovascular disease in patients with type 2 diabetes.