Investigation of vascular smooth muscle proliferation by glucose fluctuation
Project/Area Number |
21790883
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Metabolomics
|
Research Institution | Juntendo University |
Principal Investigator |
NOMIYAMA Takashi Juntendo University, 医学部, 助教 (10532559)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | エネルギー / 糖質代謝異常 / 糖尿病 / 血管平滑筋増殖 / GLP-1 / 新生内膜形成 / 血糖変動 / 血管平滑筋細胞増殖 |
Research Abstract |
Diabetes is a risk factor for atherosclerosis and the prevention of atherosclerosis is very important. We investigated the effects of GLP-1 receptor agonists (Ex-4) on vascular smooth muscle cells. Ex-4 attenuated neointimal formation after wire injury in mice. We demonstrated that the decrease in smooth muscle cell proliferation with Ex-4 may contribute the prevention of atherosclerosis. These unique effects of GLP-1R agonist may help design new therapies for cardiovascular disease in patients with type 2 diabetes.
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Report
(3 results)
Research Products
(4 results)