Effect of Thyrotropin-releasing hormone on gene expression in the islet of Langerhans of the pancreas

• Project/Area Number: 21790887
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Endocrinology
• Research Institution: Gunma University
• Principal Investigator: SHIBUSAWA Nobuyuki Gunma University, 医学部, 助教 (90396622)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 糖尿病 / マイクロアレイ / シグナル伝達 / 甲状腺刺激ホルモン放出ホルモン

Research Abstract

Thyrotropin-releasing hormone (TRH) is ubiquitously distributed throughout the brain and other tissues including pancreas. We have reported that the TRH-deficient mice (TRH^<-/->) showed characteristic tertiary hypothyroidism and also hyperglycemia, which was accompanied by impaired insulin secretion in response to glucose. To elucidate the molecular mechanism of TRH effect on insulin secretion, we conducted a microarray study with endocrine islets of mice pancreas. In the microarray analysis, 7827 genes with proper expression levels were detected in islets isolated from both TRH^<-/-> and wild type mice.

Research Products

• [Presentation] TRHによる膵ランゲルハンス島の遺伝子発現調節機構 (2010)
  • Author(s): 渋沢信行, 他
  • Organizer: 第53回日本甲状腺学会学術集会
  • Place of Presentation: 長崎ブリックホール(長崎県)
  • Year and Date: 2010-11-22
• [Presentation] TRH aff ects gene expression in the islet of Langerhans of the pancreas (2010)
  • Author(s): ガライジェニファー、渋沢信行, 他
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ、前橋元気プラザ21(群馬県)
  • Year and Date: 2010-10-02
• [Presentation] TRHの膵臓β細胞に対する作用解析 (2010)
  • Author(s): 渋沢信行, 他
  • Organizer: 第53回日本糖尿病学会年次学術総会
  • Place of Presentation: ホテルグランヴィア岡山、他(岡山県)
  • Year and Date: 2010-05-29
• [Presentation] Effect of Thyrotropin-releasing hormone on gene expression in the islet of Langerhans of the pancreas : microarray hybridization analysis of TRH-deficient mouse (2010)
  • Author(s): 渋沢信行, 他
  • Organizer: 14^<th> International Congress of Endocrinology (ICE2010)
  • Place of Presentation: 京都国際会議場(京都府)
  • Year and Date: 2010-03-30
• [Presentation] Effect of Thyrotropin-releasing hormone on gene expression in the islet of Langerhans of the pancreas : microarray hybridization analysis of TRH-deficient mouse (2010)
  • Author(s): 渋沢信行
  • Organizer: 14^<th> International Congress of Endocrinology(ICE2010)
  • Place of Presentation: 京都国際会議場(京都府)
  • Year and Date: 2010-03-30
• [Presentation] Thyrotropin-releasing hormone affects gene expression in the islet of Langerhans of the pancreas (2010)
  • Author(s): garay jennifer、渋沢信行, 他
  • Organizer: 14^<th> International Congress of Endocrinology (ICE2010)
  • Place of Presentation: 京都国際会議場(京都府)
  • Year and Date: 2010-03-27
• [Presentation] Effect of Thyrotropin-releasing hormone (TRH) on gene expression in the islet of Langerhans of the pancreas. (2009)
  • Author(s): 渋沢信行, 他
  • Organizer: 9^<th> Asia and Oceania Thyroid Association Congress (AOTA)
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2009-11-02
• [Presentation] Effect of Thyrotropin-releasing hormone(TRH)on gene expression in the islet of Langerhans of the pancreas (2009)
  • Author(s): 渋沢信行
  • Organizer: 9^<th> Asia and Oceania Thyroid Association Congress(AOTA)
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2009-11-02